Multicentric Study, Three Randomized Arms (R-CVP vs R-CHOP vs R-FM),for Patients With Stage II-IV Follicular Lymphoma

Inclusion Criteria:

1. Histological DIAGNOSIS of B cell follicular lymphoma
2. ECOG performance status 0-2
3. Age range 18-75
4. Ann Arbor Stage: II-IV
5. Assessment of pathology with diagnostics biopsy
6. Presence of one of these criteria:

   * B Sistemic symptoms B
   * Extranodale pathology
   * Cytopenia
   * Splenomegaly
   * Leukemia
   * Serous effusion
   * Ves \> 20 mm/h
   * Ldh \> normal value
   * Nodale or extranodal mass \> 7 cm
   * 3 or more nodal sites \> 3 cm
   * Adenopatic syndrome
7. LVEF \> 50%
8. Normal hepatic (bilirubin \< 1.5 mg/dl) and renal functionality (creatinin \< 2 mg/dl). If there is a lymphoma it's allow values of bilirubin \> 1.5 mg/dl and of creatinin \> 2mg/dl
9. No previous treatment for follicolar lymphoma unless RT-IF
10. Lifetime \> 6 mounth
11. Absence of HbsAg, HCV e HIV
12. Negative Coombs Test
13. Negative pregnant test
14. Cotracceptive method during the treatment and the follow three months
15. Formal written consent
16. Ability to follow the patients after the treatment for follow up

Exclusion Criteria:

1. Histological Diagnosis of all type of lymphoma unless Follicularlymphoma, CD20 lymphoma, stage IIIb of follicular lymphoma and high degree lymphoma
2. Stage I of Ann Arbor scale
3. Central Nervous system involvement
4. HIV, HBV OR HCV Positivity
5. Cardiac Pathology
6. Positive Coombs Test
7. Previous chemotherapeutic treatment
8. Hypersensitivity to antibodyes or other murine proteins
9. Previous cancer pathology unless in situ cervix and epithelial carcinomas
10. Other type of infections
11. Pregnant and nursing woman