Clinical trial · Observational
Airway Reactivity in Children Before and After BMT Bone Marrow Transplantation
Airway Reactivity in Children Before and After Bone Marrow Transplantation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: Stem cell transplantation (SCT) is associated with pulmonary complications and may lead to high morbidity and mortality. We encountered several children post-SCT with a clinical picture suggestive of airway hyper-reactivity (AHR) and evidence of reversible airway obstruction that was not reported pre-transplant. Our aim was to determine if SCT induced AHR as assessed by methacholine challenge test (MCT) and to determine any correlation between AHR and pulmonary complications. Methods: Prospective study evaluating consecutive patients referred for SCT to the Department of Pediatric Hemato-Oncology at Meyer Children's Hospital. Evaluation included pulmonary function test and methacholine challenge test before and after the transplantation, and assessment of pulmonary complications.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Positive MCT after SCT may be associated with increased risk of pulmonary complications
- timeFrame
- 3 years followup
Secondary outcomes (1)
- measure
- The number of patients with airway reactivity increased after after SCT (p < 0.05; McNemar test).
- timeFrame
- 3 years followup
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 4 Years
- Maximum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * age 4.5-20 years * ability to perform spirometry consistently * FEV1\>70% predicted Exclusion Criteria: * FEV1\<70% * inability to perform methacholine challenge test before and after stem cell transplantation.
References
Publications (0)
Data not yet available