Assessing Dynamic Magnetic Resonance (MR) Imaging in Patients With Recurrent High Grade Glioma Receiving Chemotherapy

Inclusion Criteria:

* Signed Informed Consent Form
* Age equal or greater than 18 years
* Histologically confirmed high grade glioma
* Radiographic demonstration of disease progression following prior therapy of temozolomide + radiation
* Patient scheduled for bevacizumab + standard IV chemotherapy therapy
* Bi-dimensionally measurable disease on gadolinium enhanced T1 weighted MR scans
* An interval of at least 4 weeks since prior surgical resection
* Patients corticosteroid dose must be 4 mg per day or less.
* Karnofsky performance status greater than or equal to 50
* Life expectancy greater than 12 weeks
* Ability to comply with study and follow-up procedures

Exclusion Criteria:

* Pregnant or nursing females
* Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
* Known liver function insufficiency, stage IV or V renal insufficiency
* Disease and Treatment History: Prior treatment with bevacizumab, or another vascular endothelial growth factor (VEGF) or VEGFR-targeted agent; Need for urgent palliative intervention for primary disease (e.g., impending herniation
* Bevacizumab Exclusion Criteria: History of hypertensive encephalopathy; New York Heart Association (NYHA) Grade II or greater congestive heart failure (CHF); History of myocardial infarction or unstable angina within 6 months prior to start of the study; History of stroke or transient ischemic attack within 6 months prior to study enrollment; Significant vascular disease (e.g., aortic aneurysm, aortic dissection) or recent peripheral arterial thrombosis within 6 months prior to start of the study; Evidence of bleeding diathesis or coagulopathy; on therapeutic anti-coagulants.
* Subjects unable to undergo an MRI with contrast
* Ferumoxytol Exclusion Criteria: History of allergic reactions attributed to compounds of similar chemical or biologic composition to ferumoxytol: parenteral iron, parenteral dextran, parenteral iron-dextran, or parenteral iron-polysaccharide preparations (Ferumoxytol Investigator's Drug Brochure, 2005). Patients with significant drug or other allergies or autoimmune diseases may be enrolled at the Investigator's discretion
* Subjects with known or suspected iron overload (genetic hemochromatosis or history of multiple transfusions).Patients with transferrin saturation greater than 60%
* Inability or unwillingness to undergo the complete series of imaging sessions. Inability or unwillingness to return to the neuro-oncology clinic at Oregon Health and Science University (OHSU) for the one month follow-up