Clinical trial · Observational
Blood Samples to Evaluate Biomarkers of Donor Chimerism
NCT00764829CI-TRIAL-00006270completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
We are interested in patient-specific factors that may affect the balance of recipient cells and donor cells in patients who receive stem cell transplants. We will look at the way the patient's body breaks down two drugs, fludarabine and mycophenolate mofetil, and how these two drugs affect the patient's body.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hodgkins Disease | Hodgkin Lymphoma | ALIAS | 0.90 |
| Leukemia | Leukemia | ONTOLOGY_EXACT | 0.90 |
| Myelodysplastic Syndrome | Myelodysplastic Syndrome | CURATED_BROADER | 0.80 |
| Non-hodgkins Lymphoma | Non-Hodgkin Lymphoma | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Donor T-cell chimerism
- timeFrame
- Day 28 post-transplant
Secondary outcomes (1)
- measure
- Exposure to fludarabine and mycophenolate mofetil and their breakdown products.
- timeFrame
- Before and after transplant
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with a hematologic disease or malignancy * Scheduled to receive nonablative conditioning with fludarabine and total body irradiation * Donor is well-matched by high resolution DNA techniques. * Scheduled to receive postgrafting immunosuppression of oral MMF (CellCept) and an oral calcineurin inhibitor. * Age \>18 years at the time of enrollment. Exclusion criteria: -Diagnosed with an immunodeficiency disorder
References
Publications (0)
Data not yet available
No reference posted for this study.