Clinical trial · Observational
Study of Genes and the Environment in Patients With Endometrial Cancer in the East Anglia, Oxford, Trent, or West Midlands Regions of the United Kingdom
A Population Based Study of Genetic Predisposition and Gene-Environment Interactions in Endometrial Cancer in East Anglia, Oxford Trent and West Midlands
NCT00758056CI-TRIAL-00011849unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with endometrial cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| polymorphism analysis | Genetic | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (6)
- measure
- Acquisition of epidemiological information and biological material
- measure
- The prevalence of endometrial cancer attributable to mutations in known predisposing genes such as MSH2 and MLH1
- measure
- Determination of risk associated with these predisposing mutations by examining the cancer risk in relatives of patients who are shown to be carriers
- measure
- Examination of the effect of nongenetic risk factors in mutation carriers
- measure
- The pathological and clinical characteristics of endometrial cancers occurring in mutation carriers as compared with that in noncarriers
- measure
- Exploration of mutations at other loci that may predispose to endometrial cancer
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 74 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Diagnosis of endometrial cancer within the past 5 years * Identified in any of the following geographic regions of the United Kingdom: * East Anglia * Oxford * Trent * West Midlands PATIENT CHARACTERISTICS: * Identified by the patient's general practitioner as fit to contact for this study * No serious mental illness or retardation PRIOR CONCURRENT THERAPY: * Not specified
References
Publications (0)
Data not yet available
No reference posted for this study.