Clinical trial · Interventional
Compromised Microcirculation in Women With Polycystic Ovary Syndrome
NCT00757185CI-TRIAL-00022830completedEarly Phase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The scientific aims of the study are to determine how peripheral microcirculatory responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local heating and to determine the mechanism for testosterone effects on peripheral microcirculatory responsiveness in women with PCOS.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ganirelix acetate | Drug | — | UNRESOLVED |
| methyl testosterone | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 1
- description
- GNRH antagonist alone
- interventionNames
- Drug: ganirelix acetate
- type
- EXPERIMENTAL
- label
- 2
- description
- GnRH with Testosterone
- interventionNames
- Drug: methyl testosterone
Primary outcomes (1)
- measure
- Skin blood flow and cutaneous vascular conductance
- timeFrame
- 6 non consecutive days
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: * Obese women (18-35) years with and without PCOS Exclusion Criteria: * Conditions that would preclude safe use of hormones
References
Publications (1)
- DERIVEDYoung BE, Colburn A, Oldham ZR, Berbrier D, Usselman CW, Stone T, Fadel PJ, Stachenfeld NS. Combined androgen excess polycystic ovary syndrome and obesity are associated with elevated beat-to-beat blood pressure variability in adult women. Am J Physiol Heart Circ Physiol. 2026 Aug 1;331(2):H374-H381. doi: 10.1152/ajpheart.00275.2026. Epub 2026 Jun 15. PMID 42294856