Clinical trial · Interventional
Photo-therapy With a Topical Retinoid Versus Photo-therapy Alone for Actinic Keratoses
A Randomized Controlled Paired Comparison of Photo-therapy With a Topical Retinoid Cream Pretreatment Versus PDT Alone for Actinic Keratoses
NCT00756288CI-TRIAL-00055388withdrawnN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Evaluating safety and efficacy of the use of topical retinoid with photodynamic therapy for the treatment of actinic keratoses.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Actinic Keratoses | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Photodynamic Therapy (PDT) | Procedure | — | UNRESOLVED |
| Topical retinoid and blue-light therapy with photosensitizing agent | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 1
- description
- Topical retinoid and Light therapy with photosensitizing agent
- interventionNames
- Procedure: Topical retinoid and blue-light therapy with photosensitizing agent
- type
- ACTIVE_COMPARATOR
- label
- 2
- description
- Light therapy with photosensitizing agent
- interventionNames
- Procedure: Photodynamic Therapy (PDT)
Primary outcomes (1)
- measure
- Live blinded rater and blinded photo rater analysis of areas at week 0 and week 6 for erythema, edema, crusting, ulceration, palpability, need to cease/delay treatment, and overall response in reduction of number of actinic keratoses (AKs).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria * Adults aged 18-80 years old * Subjects with AK lesions who will receive PDT * Subjects with AK lesions in two areas other than face and scalp each with a surface area of 10cm2 or greater and at least 3 clinically diagnosed non-hypertrophic AK lesions in each * Subjects in good health * Subjects with willingness and the ability to understand and provide informed consent Exclusion Criteria * Subjects who are pregnant or lactating * Subjects with a history of cutaneous photosensitivity or porphyria, hypersensitivity to porphyrins, or photodermatosis * Subjects with use of photosensitizing drugs within 1 week of study start * Subjects with use of topical medications such as corticosteroids, alpha-hydroxyacids or retinoids 2 weeks before study entry * Subjects who received previous treatment of target AKs within 4 weeks * Subjects who are unable to understand the protocol or give informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.