Effect of Intravitreal Ranibizumab on Radiation Retinopathy Following Plaque Brachytherapy for Choroidal Melanoma

Inclusion Criteria:

* Diagnosis of radiation retinopathy
* History of choroidal melanoma status post plaque brachytherapy
* Age \> 21 years
* Ability to perform written consent and comply with study assessments for the full duration of the study

Exclusion Criteria:

* Pregnancy or lactation, pre-menopausal women not using contraception
* Participation in another simultaneous medical investigation or trial
* Patient with significantly compromised visual acuity in the study eye due to concomitant ocular conditions.
* Patients who have undergone intraocular surgery within last 60 days.
* Patients who have had intravitreal anti-VEGF treatment within 45 days.
* Patients who have had intravitreal triamcinolone acetonide within 4 months.
* Patients who have had laser within 60 days.
* Inability to obtain photographs to document CNV (including difficulty with venous access).
* Patient has a history of any medical condition which would preclude scheduled visits or completion of study.
* Aphakia or absence of the posterior capsule in the study eye. Previous violation of the posterior capsule in the study eye is also excluded unless as a result of yttrium aluminum garnet (YAG) posterior capsulotomy in association with posterior chamber lens implantation..
* History of glaucoma filtering surgery in the study eye.
* Concurrent use of more than two therapies for glaucoma.
* Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated