Clinical trial · Interventional
A Random Clinical Trial (RCT) of the Impact of Electrocoagulation on Ovarian Reserve
A Random Clinical Trial of the Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Excision of Ovarian Cyst
NCT00746278CI-TRIAL-00003200completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Laparoscopic ovarian cystectomy is widely used for the removal of benign ovarian cysts but damage to ovarian reserve caused by electrocoagulation has recently been questioned. The purpose of this study is to investigate the impact of bipolar and ultrasonic scalpel electrocoagulation on ovarian reserve after laparoscopic excision of ovarian cyst.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ovarian Cyst | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laparoscopic ovarian cystectomy using bipolar | Procedure | — | UNRESOLVED |
| Laparoscopic ovarian cystectomy using suture | Procedure | — | UNRESOLVED |
| Laparoscopic ovarian cystectomy using ultrasonic scalpel | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- 1
- description
- Laparoscopic ovarian cystectomy using bipolar
- interventionNames
- Procedure: Laparoscopic ovarian cystectomy using bipolar
- type
- EXPERIMENTAL
- label
- 2
- description
- Laparoscopic ovarian cystectomy using ultrasonic scalpel electrocoagulation
- interventionNames
- Procedure: Laparoscopic ovarian cystectomy using ultrasonic scalpel
- type
- ACTIVE_COMPARATOR
- label
- 3
- description
- Laparoscopic ovarian cystectomy using suture
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * age 18-40 years * ultrasound diagnosis as unilateral ovarian cyst and the average size between 5cm and 10cm * no clinical and sonographic suspicion of ovarian cancer * regular menstrual cycles defined as cycle length between 25 and 35 days in the 6 months before surgery * sonographic normal contralateral ovary * agreement to be enrolled in the study. Exclusion Criteria: * prior ovarian surgery or known endocrine disease * surgical necessity to perform adnexectomy * intraoperative diagnosis of an abnormal contralateral ovary * post operative pathologic diagnosis was not benign ovarian cyst * oral contraceptive use before surgery.
References
Publications (5)
- BACKGROUNDCandiani M, Barbieri M, Bottani B, Bertulessi C, Vignali M, Agnoli B, Somigliana E, Busacca M. Ovarian recovery after laparoscopic enucleation of ovarian cysts: insights from echographic short-term postsurgical follow-up. J Minim Invasive Gynecol. 2005 Sep-Oct;12(5):409-14. doi: 10.1016/j.jmig.2005.06.006. PMID 16213426
- BACKGROUNDHo HY, Lee RK, Hwu YM, Lin MH, Su JT, Tsai YC. Poor response of ovaries with endometrioma previously treated with cystectomy to controlled ovarian hyperstimulation. J Assist Reprod Genet. 2002 Nov;19(11):507-11. doi: 10.1023/a:1020970417778. PMID 12484492
- BACKGROUNDLoh FH, Tan AT, Kumar J, Ng SC. Ovarian response after laparoscopic ovarian cystectomy for endometriotic cysts in 132 monitored cycles. Fertil Steril. 1999 Aug;72(2):316-21. doi: 10.1016/s0015-0282(99)00207-1. PMID 10439003
- BACKGROUNDNargund G, Cheng WC, Parsons J. The impact of ovarian cystectomy on ovarian response to stimulation during in-vitro fertilization cycles. Hum Reprod. 1996 Jan;11(1):81-3. doi: 10.1093/oxfordjournals.humrep.a019043. PMID 8671163
- BACKGROUNDSomigliana E, Ragni G, Benedetti F, Borroni R, Vegetti W, Crosignani PG. Does laparoscopic excision of endometriotic ovarian cysts significantly affect ovarian reserve? Insights from IVF cycles. Hum Reprod. 2003 Nov;18(11):2450-3. doi: 10.1093/humrep/deg432. PMID 14585900