Health Benefits of Vitamin D and Calcium in Women With PCOS (Polycystic Ovarian Syndrome)

Inclusion Criteria:

* Premenopausal women (ages 18-40 years) with normal thyroid function and prolactin levels.
* PCOS diagnosis based on Rotterdam criteria: presence of at least 2 of the following criteria:

  * oligomenorrhea-menstrual cycles \> 35 day intervals
  * hyperandrogenemia (elevated serum testosterone \[free or total\] \&/or androstenedione levels) or features of hyperandrogenism i.e. acne or hirsuitism \[Ferriman-Gallaway score \> 3\]
  * polycystic ovaries on vaginal ultrasound as defined by ESHRE/ASRM criteria (ovarian volume ≥ 10mL or ≥ 12 follicles of diameter between 2-9mm in at least one ovary)
  * Overweight (BMI ≥ 27 Kg/m2)
  * Biochemical evidence of Vitamin D insufficiency (i.e. serum 25 OHD levels \< 20ng/mL)

Exclusion Criteria:

* Pregnancy
* Known causes of oligomenorrhea other than PCOS, e.g. hypothyroidism/Cushing's Disease/late onset congenital adrenal hyperplasia (fasting 17-alphahydroxyprogesterone levels \< 200ng/dL)
* Use of hormonal treatment (birth control pill/patch/depot medroxyprogesterone/medroxyprogesterone) within 3 months of the study onset.
* Use insulin sensitizers (metformin, sulfonylureas, TZDs, incretins) within 3 months of the study onset.
* Use of lipid lowering agents or medications known to influence insulin sensitivity (e.g. niacin, corticosteroids, beta blockers, calcium channel blockers, thiazide diuretics) or influence serum androgens (estrogen, anti-androgens, androgens) within 3 months of the study onset.
* Known history of renal calculi or current use of Calcium and Vitamin D supplements.
* Spanish Speaking.