Intravenous AMD3100 for Collection of Autologous Peripheral Blood Stem Cells in Patients With Lymphoma

Inclusion Criteria:

* Age 18 to 75 years
* Diagnosis of HL or NHL eligible for autologous transplantation
* 30 days since last cycle of chemotherapy
* ECOG performance status of 0 or 1
* The patient has recovered from all acute toxic effects of prior chemotherapy
* WBC \>3.0 X 109/l
* Absolute PMN count \>1.5 X 109/l
* PLT count \>100 X 109/l
* Serum creatinine ≤ 2.2 mg/dl
* AST (SGOT), ALT (SGPT) and total bilirubin \< 2X upper limit of normal (ULN)
* Left ventricle ejection fraction \> 45% (by ECHO or MUGA scan)
* FEV1 \> 60% of predicted or DLCO \> 45% of predicted
* Negative for HIV on standard transplant workup
* Signed informed consent
* Are surgically or biologically sterile or willing to practice acceptable birth control, as follows:

  * Females of child bearing potential must agree to abstain from sexual activity or to use a medically approved contraceptive measure/regimen during and for 3 months after the treatment period. Women of child bearing potential must have a negative serum or urine pregnancy test at the time of enrollment. Acceptable methods of birth control include oral contraceptive, intrauterine device (IUD), transdermal/implanted or injected contraceptives and abstinence.
  * Males must agree to abstain from sexual activity or agree to utilize a medically approved contraception method during and for 3 months after the treatment period

Exclusion Criteria:

* A co-morbid condition which, in the view of the investigator, renders the patient at high risk for treatment complications
* Patients who have failed previous collections
* A residual acute medical condition resulting from prior chemotherapy
* Acute infection
* Fever (temp \>38C/100.4F) on the day of start of treatment
* Positive pregnancy test in female patients
* Lactating females
* Patients of child bearing potential unwilling to implement adequate birth control
* Patients whose actual body weight exceeds 150% of their ideal body weight
* History of ventricular arrhythmias
* Patients who previously received experimental therapy within 4 weeks of enrolling in this study or who are currently enrolled in another experimental study during the mobilization phase
* Patients who have deterioration of their clinical status or laboratory parameters between the time of enrollment and transplantation such that they no longer meet entry criteria may be removed from study at the discretion of the treating physician, principal investigator, or sponsor