Sutent + Taxol for Advanced Esophageal Cancer

Inclusion Criteria:

* Histologically confirmed recurrent or metastatic esophageal or gastro-esophageal junction squamous cell or adenocarcinoma
* Measurable or evaluable disease per RECIST within 28 days prior to being registered on protocol therapy.
* No more than one prior chemotherapy regimen for locally advanced or metastatic disease is allowed.
* Written informed consent and HIPAA authorization for release of personal health information. NOTE: HIPAA authorization may be included in the informed consent or obtained separately.
* Age \> 18 years.
* Females of childbearing potential and males must be willing to use an effective method of contraception (hormonal or barrier method of birth control; abstinence) while on treatment and for 3 month period thereafter.
* Females of childbearing potential must have a negative pregnancy test within 7 days prior to being registered for protocol therapy. Subjects are considered not of child bearing potential if they are surgically sterile (they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal.
* Females must not be breastfeeding.
* Must be willing to comply with study and follow up procedures.

Exclusion Criteria:

* No history of inadequately controlled hypertension (Systolic Blood Pressure \> 150 or Diastolic Blood Pressure \> 100) on a standard regimen of antihypertensive therapy.
* No prior treatment with vascular endothelial growth factor (VEGF) inhibitor, epidermal growth factor receptor (EGFR) inhibitor, or other anti-angiogenic agent.

No serious, non-healing wound, ulcer, or bone fracture.

* No history of or current hemoptysis.
* No history of transient ischemic attack (TIA) or stroke within 12 months prior to registration for protocol therapy.
* No evidence of bleeding diathesis, coagulopathy, prolonged INR or PTT.
* No chronic anti-coagulation treatment.
* No history of central nervous system or brain metastases.
* No history of any major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to registration for protocol therapy, or anticipation of need for major surgical procedure during the course of protocol therapy.
* No history of any minor surgical procedures such as fine needle aspirations or core biopsies within 7 days prior to registration for protocol therapy.
* No history of clinically significant peripheral neuropathy, i.e., Grade \> 3 neuromotor or neurosensory toxicity as defined by NCI CTCAE v 3.0.
* No known history of adrenal insufficiency documented by adrenocorticotropic hormone (ACTH) stimulation testing.
* No prolonged corrected QT (QTc) interval on pre-entry electrocardiogram (\> 450 msec), obtained within 28 days prior to being registered for protocol therapy.
* No other active cancers
* No clinically significant infections as judged by the treating investigator.
* No history of a seizure disorder.
* No known history of hypersensitivity to paclitaxel.
* No CYP3A4 inducers and inhibitors allowed within 14 days prior to registration on protocol therapy and while receiving the protocol therapy.