Clinical trial · Interventional
Trial With Azacitidine in Newly Diagnosed Acute Myelogenous Leukemia (AML) Veterans Administration (VA) Elderly Patients Not Eligible for Standard Induction Therapy
A Phase II Trial With Azacitidine Single Agent in Newly Diagnosed Acute Myelogenous Leukemia (AML) Veterans Administration (VA) Elderly Patients Who Are Ineligible for Standard Induction Therapy: A Department of Veterans Affairs Multi-Site Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The drug that will be used in this study is called Azacitidine. Azacitidine belongs to a group of drugs which may restore normal control in cancer cells by affecting the genes and proteins in the body. Azacitidine is approved by the FDA for the treatment of Myelodysplastic Syndrome (MDS), a pre-leukemic bone marrow disease. The purpose of this study is to find out what effect the drug Azacitidine has on Acute Myeloid Leukemia (AML) in elderly patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Myeloid Leukemia | Acute Myeloid Leukemia | CURATED_BROADER | 0.80 |
| Elderly | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Azacitidine | Drug | Azacitidine | ALIAS |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- overall response rates, duration of response, toxicities
- timeFrame
- Starting 4 weeks after treatment, during the entire study duration, and upon study completion
Secondary outcomes (1)
- measure
- leukemia free survival, overall survival, quality of life, assess biomarkers and predictive markers for Azacitidine responsiveness in elderly AML patients
- timeFrame
- During the entire duration of the study and after study completion
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of AML * Elderly patients with denovo AML or secondary AML evolving from MDS in patient \>/= 60 who decline chemotherapy or those who are not currently candidates for induction chemotherapy * Stable WBC \<10 x 109 and not requiring hydroxyurea, chemotherapy or leukapheresis for \>4 weeks * No corticosteroids, hydroxyurea, low-dose cytarabine, interferon, ir retinoids within 1 month * No prior decitabine * No valproic acid or other histone deacetylase inhibitor for at least 2 weeks * No G-CSF, or GM-CSF or Erythropoetin within 1 month of study entry * No investigational agents within 28 days * ECOG performance status \</= 2 or KPS \>/= 60% * Life expectancy \> 2 months * Normal organ function = Total bilirubin \</= 1.5 x ULN, AST/ALT \</= 2.5 x ULN * Creatinine within normal limits or creatinine clearance \>/= 60ml/min * Signed informed consent Exclusion Criteria: * Patients with t(15;17) or M3-AML * Patients who have had chemotherapy or radiotherapy within 4 weeks prior to study entry, or who have not recovered from adverse effects of agents administered earlier * Patients with CNS involvement of AML * History of allergic reactions attributed to Azacitidine or compounds of similar chemical used in this study * Pregnancy * Other serious medical or psychiatric illness which would limit survival to \< 3 months or prevent the granting of informed consent or lead to situations that would limit compliance with study requirements * Known positive serology for HIV, HIV positive patients with anti-retroviral therapy are ineligible * Active systemic bacterial, fungal or viral infection * Patients with severe complications of the leukemia including but not limited to active infection, uncontrolled infection, pneumonia, hypoxia, and shock * Patients with advanced hepatic tumors * Patients with poor history of medical compliance * Patients with known platelet refractoriness
References
Publications (0)
Data not yet available