Clinical trial · Interventional
Effect of I/R Injuries by Pringle Manoeuvre on the Prognosis of HCC Patients After Curative Hepatectomy
The Effect of Ischemia/Reperfusion Injuries Elicited by Pringle Manoeuvre on the Prognosis of HCC Patients After Curative Excision:A Multicenter Prospective Randomized Controlled Trial
NCT00725335CI-TRIAL-00008538completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a multi-centre prospective randomized controlled trial to explore the influence of ischemia-reperfusion injuries elicited by pringle manoeuvre during radical excision on the prognosis of Hepatocellular Carcinoma (HCC) patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| curative resection without Pringle | Procedure | — | UNRESOLVED |
| curative resection with Pringle manoeuvre | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- group A,non-pringle group
- description
- Intervention of curative resection of HCC Without pringle manoeuvre in this arm
- interventionNames
- Procedure: curative resection without Pringle
- type
- ACTIVE_COMPARATOR
- label
- pringle group(B)
- description
- when the curative resection of HCC performed, the pringle manoeuvre will be routinely applied.
- interventionNames
- Procedure: curative resection with Pringle manoeuvre
Primary outcomes (1)
- measure
- Disease free survival
- timeFrame
- 1,3,5-year
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Clinical diagnosis of resectable primary liver cancer * The liver function showed:Child-Pugh A，ICG-R15 \< 20% * HbsAg (+) * tumor nodes in the liver were singular or multiple and could be radical excision * No preoperative anti-cancer therapy * Written informed consent from the patient or legal guardian prior to entering the study Exclusion Criteria: * Pregnancy patients * With extrahepatic tumor or lymphnode metastasis * Tumor invasion or thrombosis in portal vein,hepatic vein or inferior vena cava * Positive marginal
References
Publications (1)
- DERIVEDXiaobin F, Shuguo Z, Jian Z, Yudong Q, Lijian L, Kuansheng M, Xiaowu L, Feng X, Dong Y, Shuguang W, Ping B, Jiahong D. Effect of the pringle maneuver on tumor recurrence of hepatocellular carcinoma after curative resection (EPTRH): a randomized, prospective, controlled multicenter trial. BMC Cancer. 2012 Aug 3;12:340. doi: 10.1186/1471-2407-12-340. PMID 22862951