Clinical trial · Interventional
Amiodarone Prophylaxis for Atrial Fibrillation in Patients Undergoing Surgery for Lung Cancer
Amiodarone Prophylaxis for Atrial Fibrillation in Patients Undergoing Surgery for Lung Cancer: A Controlled, Randomized, Double Blinded Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients undergoing lung resection due to pulmonary cancer can be compromised in their postoperative period due to atrial fibrillation. A retrospective analysis performed at our institution indicates that 30 % of the population develope atrial fibrillation in the postoperative period. Amiodarone is known to diminish the occurence of postoperative atrial fibrillation after heart surgery, why this drug is chosen as a prophylactic agent for the mentioned population. Amiodarone is administrated twice a day for 5 days at a dose of 600 mg oral treatment after an initial loading bolus og 300 mg intravenously.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Atrial Fibrillation | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Amiodarone | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- A
- interventionNames
- Drug: Amiodarone
Primary outcomes (1)
- measure
- Free of atrial fibrillation
- timeFrame
- 31082009
Secondary outcomes (1)
- measure
- Cost-benefit analysis of amiodarone prophylactic
- timeFrame
- 31082009
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Resection of the lung due to confirmed diagnosis of cancer pulmones. * Elective operation (scheduled operation for at least one day) * Ready to be randomized * Patient must be at least 18 at time of operation Exclusion Criteria: * Former operation of the lung * Former heart surgery * Bradycardia below 40 beats/ min * Hypotension with systolic blood pressure below 80 mmHg * AV-blockage of any degree or sick sinus node * QTc interval above 440 ms for men or above 460 ms for women * Paroxysmal, persistent or permanent atrial fibrillation or flutter * Former atrial fibrillation or flutter for more than a month. * Pregnant or positive pregnancy test * Breastfeeding * ALAT of more than twice the normal over limit * Treatment with monoamineoxidase inhibitors (MAOI) * Allergy to one or more components in amiodarone
References
Publications (0)
Data not yet available