A Phase I Trial of Bortezomib and Sunitinib

Inclusion Criteria:

Each patient must meet all of the following inclusion criteria to be enrolled in the study:

* Refractory advanced solid tumor that has failed standard therapy.
* ECOG PS ≤ 2
* Voluntary written informed consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care.
* Female subject is either post-menopausal or surgically sterilized or willing to use an acceptable method of birth control (i.e., a hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) for the duration of the study.
* Male subject agrees to use an acceptable method for contraception for the duration of the study.
* Cardiac ejection fraction is more than 45%

Exclusion Criteria:

* Patient has a platelet count of \<100 x 109/L within 14 days before enrollment.
* Patient has an absolute neutrophil count of ANC \<1.0 x 109/L within 14 days before enrollment.
* Patient has a calculated or measured creatinine clearance of \<30 mL/minute within 14 days before enrollment.
* AST, ALT, total bilirubin \> twice the upper limits of normal.
* Received radiation to more than 30% of marrow volume
* Patient has greater than or equal to Grade 2 peripheral neuropathy within 14 days before enrollment.
* Myocardial infarction within 6 months prior to enrollment or has New York Heart Association (NYHA) Class III or IV heart failure (see section 8.4), uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Prior to study entry, any ECG abnormality at Screening has to be documented by the investigator as not medically relevant.
* Patient has hypersensitivity to sunitinib, bortezomib, boron or mannitol.
* Uncontrolled hypertension
* History of venous thromboembolic events.
* Female subject is pregnant or breast-feeding. Confirmation that the subject is not pregnant must be established by a negative serum Beta-human chorionic gonadotropin (Beta-hCG) pregnancy test result obtained during screening. Pregnancy testing is not required for post-menopausal or surgically sterilized women.
* Patient has received other investigational drugs with 14 days before enrollment
* Serious medical or psychiatric illness likely to interfere with participation in this clinical study.
* Hemorrhagic tendency of the tumor