Clinical trial · Interventional
Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer (EOC): A Phase III Randomized Study
Neoadjuvant Chemotherapy (NACT) Followed by Interval Debulking Surgery vs Upfront Surgery Followed by Chemotherapy (CT) in Advanced Epithelial Ovarian Carcinoma (EOC): A Prospective Randomized Study
NCT00715286CI-TRIAL-00001570unknownPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To determine the impact of Neoadjuvant chemotherapy on surgical debulking rate, overall and disease-free survival and quality of life (QOL) in patients with advanced EOC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ovarian Carcinoma | Ovarian Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| timing of surgery | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- A
- description
- Conventional arm: primary surgery followed by chemotherapy
- interventionNames
- Other: timing of surgery
- type
- EXPERIMENTAL
- label
- B
- description
- Neoadjuvant chemotherapy followed by interval debulking
- interventionNames
- Other: timing of surgery
Primary outcomes (1)
- measure
- to compare the optimal debulking rate in primary surgery group and neoadjuvant chemotherapy group
- timeFrame
- post surgery
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Age:20 to 65 years * Epithelial ovarian carcinoma * Stage IIIc \& IV (pleural effusion only) * ECOG PS 0-2 * Cytology/biopsy positive patients * Good compliance * Previously untreated patients Exclusion Criteria: * Any medical contraindication of surgery * Psychiatric illness * Cardiac, liver or renal dysfunction
References
Publications (0)
Data not yet available
No reference posted for this study.