Screening for Early Pancreatic Neoplasia (Cancer of the Pancreas Screening or CAPS4 Study)

Inclusion Criteria:

1. High Risk Group 1 (familial Peutz-Jeghers syndrome):

   1. At least 30 years old and \<100 years old, and
   2. at least 2 of 3 criteria diagnostic of Peutz-Jeghers syndrome (characteristic intestinal hamartomatous polyps, mucocutaneous melanin deposition, or family history of Peutz-Jeghers syndrome)
   3. known STK-11 gene mutation carrier
2. High Risk Group 2 (familial pancreatic cancer relatives):

   1. \> 50 years old or 10 years younger than the age of youngest relative with pancreatic cancer, and \< 80 years old
   2. come from a family with 2 or more members with a history of pancreatic cancer (2 of which have a first-degree relationship consistent with familial pancreatic cancer), and
   3. have a first-degree relationship with at least one of the relatives with pancreatic cancer.

   If there are 2 or more affected blood relatives, at least 1 must be a first-degree relative of the individual being screened
3. High Risk Group 3 (germline mutation carriers):

   1. \> 40 years old or 10 years younger than the age of the youngest relative with pancreatic cancer, and\< 80 years old
   2. patient is carrier of a known BRCA1, BRCA2, PALB2, or FAMMM (p16/CDKN2A) mutation, and there is \> 1 pancreatic cancer in the family, one of whom is a first- or second-degree relative of the subject to be screened.
   3. Hereditary pancreatitis syndrome
4. High Risk Group 4 (young-onset pancreatic cancer relative):

   1. \> 50 years old or 10 years younger than the age of youngest relative with pancreatic cancer, and \< 80 years old
   2. have a first-degree relationship with at least one relative with young-onset pancreatic cancer ( age of onset \< 50 years)
5. High risk group 5 (both parents affected)

   1. \> 50 years old or 10 years younger than the age of the youngest relative with pancreatic cancer, and\< 80 years old
   2. two parents affected by pancreatic cancer
6. Control 1 (Negative Controls):

   1. are undergoing EUS and/or ERCP for non-pancreatic indications as part of their standard medical care, and
   2. have no clinical or radiologic suspicion of pancreatic disease (chronic pancreatitis or pancreatic cancer)
7. Control 2 (Chronic Pancreatitis)

   1. are undergoing EUS and/or ERCP for evaluation and/or treatment of suspected or proven chronic pancreatitis as part of their standard medical care, and,
   2. have no clinical or radiologic suspicion of pancreatic cancer
8. Control 3 (Pancreatic Cancer)

   a. are undergoing EUS and/or ERCP for evaluation and/or treatment of suspected or proven pancreatic ductal adenocarcinoma (based on clinical and radiologic evidence)
9. Control 4 (Intraductal Papillary Mucinous Neoplasm or IPMN) a. are undergoing EUS and/or ERCP for evaluation and/or treatment of suspected or proven pancreatic cancer precursor, intraductal papillary mucinous neoplasm (based on clinical presentation and radiologic or prior EUS or radiologic evidence of a dilated main pancreatic duct and/or pancreatic cystic lesion communicating with the pancreatic ductal system)

Additional requirements for eligible high risk patients: i) All persons with known genetic mutation must have proof of mutation status. Those who had research-related genetic testing must have confirmation by a clinical CLIA-certified laboratory. ii) A good faith attempt should be made to confirm pancreatic cancers in the family members via registration in a pancreatic cancer registry iii) The affected first degree relative of the person being screened must be confirmed by medical record or death certificate.

All control patients must be \> 18 and \< 80 years old and no personal or family history of pancreatic cancer or a germline mutation linked to pancreatic cancer.

Exclusion Criteria:

Patients will be excluded if they have any of the following:

1. medical comorbidities or coagulopathy that contraindicate endoscopy,
2. Karnosfky performance status of \< 60,
3. had partial or complete resection of their pancreas
4. had a partial or complete gastrectomy with Billroth or Roux-en-Y anastomosis
5. a stricture or obstruction in the upper GI tract that does not allow passage of the echoendoscope
6. life expectancy less than 5 years due to coexisting advanced cancer or AIDS.
7. inability to provide informed consent
8. pregnant patient
9. history of pancreatic cancer,
10. suspicion of pancreatic neoplasia based on clinical history (weight loss, unexplained abdominal pain), physical examination (obstructive jaundice, cachexia), laboratory tests (cholestastic liver function tests, markedly elevated CA19-9), and/or imaging studies (pancreatic mass or cyst, dilated pancreatic and/or bile duct);
11. there is no interest in undergoing treatment of pancreatic neoplasm(s) detected by screening.
12. history of chronic kidney disease, serum creatinine \> 2.0 mg/dl or estimated glomerulofiltration rate (eGFR) \< 30 ml/min, ongoing acute renal failure, cirrhosis of the liver, chronic hepatitis (The estimated glomerulfiltration rate (eGFR) will be calculated based on age, race, and serum creatinine, using the on-line calculator at nephron.com).
13. history of dementia