Clinical trial · Interventional
Treatment of Adolescent Polycystic Ovary Syndrome (PCOS)
Treatment of Polycystic Ovary Syndrome (POS) in Overweight Adolescents
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A 24 week study to compare the use of Metformin, birth control pills and a carefully planned intensive lifestyle program that includes weight loss and exercise. These approaches will be compared to placebo (a pill that contains no active substances. Metformin, birth control pills and the lifestyle management program will be used on this research study to compare their ability to: 1. reduce fasting glucose levels 2. reduce androgen hormone levels 3. improve sex steroid binding, and 4. improve lipids (fatty substances in the blood)
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lifestyle Modification | Behavioral | — | UNRESOLVED |
| Metformin | Drug | Metformin | ALIAS |
| Oral Contraceptive Pills (Yasmin) | Drug | — | UNRESOLVED |
| placebo | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- 1
- description
- Metformin
- interventionNames
- Drug: Metformin
- type
- EXPERIMENTAL
- label
- 2
- description
- Oral Contraceptive Pills
- interventionNames
- Drug: Oral Contraceptive Pills (Yasmin)
- type
- ACTIVE_COMPARATOR
- label
- 3
- description
- lifestyle modification program
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 12 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Menstrual irregularity defined as cycle length \> 45 days * Overweight as BMI \> 25 * Clinical evidence of hirsuitism or acne * Testosterone \> 50ng/dL Exclusion Criteria: * History of diabetes mellitus * History of Cushing's disease * History of hyperprolactinemia * Untreated hypo or hyperthyroidism * History of adrenal hyperplasia * Significant renal impairment * Received oral contraceptives, estrogen or progestin or other drugs known to effect lipoprotein metabolism within 2 months of starting the study * Exercise \> 10 hours per week
References
Publications (0)
Data not yet available