Clinical trial · Interventional
Hypoxia-positron Emission Tomography (PET) and Intensity Modulated Proton Therapy (IMPT) Dose Painting in Patients With Chordomas
Hypoxia-PET and IMPT Dose Painting in Patients With Chordomas: A Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Before radiation treatment is given to treat chordomas, CT and MRI scans are used to create a three dimensional picture of the tumor using x-rays. The CT and MRI scans are used to determine the size and location of the area that will receive radiation treatment. The purpose of this research study is to see if combining the images from the FMISO-PET scan and the CT and MRI scans in radiation treatment planning changes the size and location of the area that will receive radiation treatment when compared to planning the radiation treatment with CT and MRI scans alone.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chordoma | Chordoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Fluoromisonidazole-PET/CT | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- (18F)-FMISO/CT
- description
- The study utilizes PET/CT scanning with (18F)-FMISO/CT in addition to standard used CT and MRI. Patients enrolled in this trial completed 2 PET/CT investigations, the first before proton radiation therapy and the second at a dose of approximately 30 Gy (24-36 Gy).
- interventionNames
- Procedure: Fluoromisonidazole-PET/CT
Primary outcomes (1)
- measure
- To evaluate if FMISO-PET is a feasible approach for the visualization of hypoxia in skull base and spinal CD.
- timeFrame
- 2 years
Secondary outcomes (2)
- measure
- To investigate if using a Dose Painting/IMPT approach based on FMISO-PET/CT/MRI the irradiation dose can be escalated and the normal tissue be better spared in comparison to a IMPT approach based on anatomical imaging alone.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Skull base and spinal chordomas diagnosis based on pathology review by Department of Pathology at Massachusetts General Hospital * Patient to be treated with proton or combined photon RT for primary CD or recurrent CD after surgery * 18 years of age or older * Karnofsky Score of 60% or greater * Gross tumor mass larger than 1cm (maximal diameter on MRI) Exclusion Criteria: * Recurrences after RT * Pregnancy * Allergic reaction to FMISO injection
References
Publications (0)
Data not yet available