Clinical trial · Interventional
Study to Examine the Effect of HKI-272 on Rhythms of the Heart (Cardiac Repolarization)
A Single Dose, Crossover, Placebo- and Moxifloxacin-Controlled Study of the Effects of HKI-272 on Cardiac Repolarization in Healthy Adult Subjects
NCT00708903CI-TRIAL-00006893completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether HKI-272 affects the rhythms of the heart (cardiac repolarization).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Moxifloxacin | Drug | — | UNRESOLVED |
| neratinib | Drug | Neratinib | ALIAS |
| Placebo | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- 1
- description
- HKI-272
- interventionNames
- Drug: neratinib
- type
- PLACEBO_COMPARATOR
- label
- 2
- description
- Placebo
- interventionNames
- Other: Placebo
- type
- ACTIVE_COMPARATOR
- label
- 3
- description
- Moxifloxacin
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Men or women of nonchildbearing potential, * 18-50 years old. * Healthy as determined by the investigator, including physical examination, laboratory test results, and medical history.
References
Publications (0)
Data not yet available
No reference posted for this study.