Clinical trial · Observational
The Expression of Antigens in Bone Marrow Samples From Volunteering Donors.
Analysis of Expression of Antigens in Bone Marrow Samples From Volunteering Donors.
NCT00706199CI-TRIAL-00031530completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Antigen expression levels in bone marrow from volunteering donors will be analyzed. The results of this analysis will be used to establish a clinical test to identify cancer patients who could qualify to receive an investigational treatment being developed by GlaxoSmithKline.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bone marrow aspiration | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Group A
- description
- donors
- interventionNames
- Procedure: Bone marrow aspiration
Primary outcomes (2)
- measure
- Number of copies of Wilms' Tumor 1 (WT1) antigen expression in bone marrow
- timeFrame
- At Day 0
- description
- Establishment of the range of WT1 transcript levels in a collection of bone marrow samples by real-time quantitative RT-PCR (Reverse Transcription Polymerase Chain Reaction). Due to the low numbers, they were expressed as \[value x 10E-03\]. Only the samples with gene expression \>0 were presented.
- measure
- Number of copies of PRAME (Preferentially expressed in melanoma)antigen expression in bone marrow
- timeFrame
- At Day 0
- description
- Establishment of the range of PRAME transcript levels in a collection of bone marrow samples by real-time quantitative RT-PCR (Reverse Transcription Polymerase Chain Reaction). Due to the low numbers, they were expressed as \[value x 10E-03\]. Only the samples with gene expression \>0 were presented.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * The donor is aged \>= 18 years * Written informed consent has been obtained prior to the performance of any specific procedure. * The donor has a medical indication for which a bone marrow aspiration is planned. * The donor is eligible for a bone marrow aspiration.
References
Publications (0)
Data not yet available
No reference posted for this study.