Clinical trial · Interventional
Study of CGC-11047 When Used in Individual Combinations With 1) Gemcitabine or 2) Docetaxel or 3) Bevacizumab or 4) Erlotinib or 5) Cisplatin or 6) 5-Flurouracil or 7) Sunitinib in Patients With Advanced Solid Tumors or Lymphoma
A Phase I Open Label, Multicenter, Dose-Escalation Study to Determine the Maximum Tolerated Dose, Dose Limiting Toxicity, Safety and Pharmacokinetics of CGC-11047 When Used in Individual Combinations With 1) Gemcitabine or 2) Docetaxel or 3) Bevacizumab or 4) Erlotinib or 5) Cisplatin or 6) 5-Flurouracil or 7) Sunitinib in Patients With Advanced Solid Tumors or Lymphoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will aims to determine the maximum tolerated dose of CGC-11047 when used in individual combinations with gemcitabine, or docetaxel, or bevacizumab, or erlotinib or cisplatin or 5-flurouracil or sunitinib in one of 7 treatment arms. The dose of CGC-11047 will be escalated until the maximum tolerated dose is established.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CGC-11047 and 5-flurouracil / leucovorin | Drug | — | UNRESOLVED |
| CGC-11047 and bevacizumab | Drug | — | UNRESOLVED |
| CGC-11047 and cisplatin | Drug | — | UNRESOLVED |
| CGC-11047 and docetaxel | Drug | — | UNRESOLVED |
| CGC-11047 and erlotinib | Drug | — | UNRESOLVED |
| CGC-11047 and gemcitabine | Drug | — | UNRESOLVED |
| CGC-11047 and sunitinib | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (7)
- type
- EXPERIMENTAL
- label
- 1
- description
- CGC-11047 in combination with Gemcitabine
- interventionNames
- Drug: CGC-11047 and gemcitabine
- type
- EXPERIMENTAL
- label
- 2
- description
- CGC-11047 in combination with Docetaxel
- interventionNames
- Drug: CGC-11047 and docetaxel
- type
- EXPERIMENTAL
- label
- 3
- description
- CGC-11047 in combination with Bevacizumab
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * non-hematological advanced solid tumor malignancy or lymphoma where no curative therapy exists in which monotherapy with gemcitabine or docetaxel or bevacizumab or erlotinib or cisplatin, or 5-flurouracil or sunitinib would otherwise be warranted. * measurable disease based on radiographic evaluation or elevated tumor markers. * ECOG - 0 or 1 (KPS \>70). * Life expectancy \> 3 months. Exclusion Criteria: * chemotherapy within 21 days or radiotherapy within 4 weeks prior to entering the study * known active brain metastases or leptomeningeal carcinomatosis. * history of a myocardial infarction within the prior 6 months or, hospitalizations for congestive heart failure within the prior 6 months, or active treatment for uncontrolled cardiac arrhythmias * clinically significant gastrointestinal tract hemorrhage, requiring transfusion therapy, within the prior 3 months.
References
Publications (0)
Data not yet available