Clinical trial · Interventional
Pemetrexed, Cisplatin, and Radiation Therapy in Treating Patients With Esophageal or Gastroesophageal Junction Cancer
Phase I Study of Concomitant Pemetrexed and CDDP Plus Radiation Therapy in Patients With Locally Advanced or Metastatic Esophageal or Gastroesophageal (GEJ) Carcinomas
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Pemetrexed may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Cisplatin may make tumor cells more sensitive to radiation therapy. Giving pemetrexed together with cisplatin and radiation therapy may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of pemetrexed when given together with cisplatin and radiation therapy in treating patients with stage III or stage IV esophageal cancer or gastroesophageal junction cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| cisplatin | Drug | Cisplatin | ALIAS |
| Pemetrexed | Drug | Pemetrexed | ALIAS |
| radiation therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Pemetrexed, Cisplatin, Radiation Therapy
- description
- Concomitant Pemetrexed and CDDP Plus Radiation Therapy
- interventionNames
- Drug: cisplatin
- Drug: Pemetrexed
- Radiation: radiation therapy
Primary outcomes (1)
- measure
- The maximum tolerated dose (MTD) of pemetrexed
- timeFrame
- 6 months
Secondary outcomes (2)
- measure
- Toxicity profile
- timeFrame
- 12 months
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 120 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Diagnosis of esophageal or gastroesophageal junction carcinoma * Stage III or IV disease * Treatment with chemoradiotherapy is considered appropriate * Measurable or evaluable disease * Clinically significant pleural or pericardial effusions or ascites allowed provided they were drained prior to study entry * No pleurodesis within the past 2 weeks * Controlled brain metastasis allowed provided patient is clinically stable with no signs of progression by MRI or CT scan of the brain ≥ 60 days after completion of treatment AND is asymptomatic and does not require steroids PATIENT CHARACTERISTICS: * ECOG performance status 0-2 * Life expectancy ≥ 12 weeks * WBC ≥ 2,500/mm\^3 * ANC ≥ 1,500/mm\^3 * Hemoglobin ≥ 9 g/dL * Platelet count ≥ 100,000/mm\^3 * Total bilirubin normal * Alkaline phosphatase AND AST and ALT meeting the following criteria: * Alkaline phosphatase normal AND AST or ALT ≤ 3 times upper limit of normal (ULN) (≤ 5 times ULN for patients with liver metastases) * Alkaline phosphatase ≤ 2.5 times ULN AND AST or ALT ≤ 1.5 times ULN * Alkaline phosphatase ≤ 5 times ULN AND AST or ALT normal * Creatinine clearance ≥ 45 mL/min * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception during and for 3 months after completion of study therapy * Able to take folic acid, vitamin B\_12, or corticosteroids * No known severe hypersensitivity reaction to study drugs * No uncontrolled serious active infection * No pre-existing peripheral neuropathy \> grade 1 * No significant cardiac disease, including any of the following: * Uncontrolled high blood pressure * Unstable angina * Congestive heart failure within the past 6 months * Left ventricular ejection fraction below the lower limit of normal * Myocardial infarction within the past year * Serious cardiac arrhythmias requiring medication PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No prior systemic therapy regimens * No prior radiotherapy to gastric/esophageal fields * No aspirin or other NSAID before and after pemetrexed disodium administration * No concurrent colony-stimulating factors (CSF) to maintain WBC and ANC eligibility values
References
Publications (1)
- DERIVEDElquza E, Babiker HM, Howell KJ, Kovoor AI, Brown TD, Patel H, Malangone SA, Borad MJ, Dragovich T. Phase I Study of Concomitant Pemetrexed and Cisplatin Plus External Beam Radiation Therapy in Patients with Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Carcinomas. Cancer Invest. 2016;34(2):57-63. doi: 10.3109/07357907.2015.1108426. Epub 2016 Jan 25. PMID 26810581