Clinical trial · Observational
International Pediatric Adrenocortical Tumor Registry
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to collect demographic and medical information including detailed family history of cancer of children and adolescents with adrenocortical tumors in order to learn more about the clinical and epidemiological aspects, treatment modalities, and outcome of patients with this rare disease, worldwide. In addition, investigators at St. Jude Children's Research Hospital (SJCRH) plan to perform molecular studies of tumor cells aimed to clarify the role of the TP53 gene and other genetic pathways in these tumors. They aim to obtain relevant biological material from participants with adrenocortical tumor (ACT), their biological parents, and relatives for determination of the TP53 germline status, molecular studies of the TP53 gene, and other molecular pathways.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adrenocortical Tumor | Adrenal Cortical Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Participants
- description
- Any participant who meets eligibility criteria and consents to participate in the trial.
Primary outcomes (1)
- measure
- Collect demographic/medical information, detailed family history of cancer of children/adolescents with adrenocortical tumors, learn more about the clinical and epidemiological aspects, treatment modalities, and outcome of patients
- timeFrame
- Annually from diagnosis until no longer being followed, defined as up to 5 years from the date of last follow-up
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 21 Years
Show eligibility criteria text
STRATIFICATION ASSIGNMENT: * Stratum A: participant suspected or confirmed diagnosis of adrenocortical tumor (ACT) * Stratum R: relative of participant with ACT and TP53 mutation who has diagnosis of malignancy * Stratum P: biological parent of participant with ACT Inclusion Criteria - Stratum A (participant with ACT): * Age ≤ 21 years old at diagnosis * Suspected or confirmed diagnosis of adrenocortical tumor (adenoma, carcinoma or undefined histology). * Signed informed consent Inclusion Criteria - Stratum R (relative): * Any age * Diagnosis of malignant tumor * Signed informed consent Inclusion Criteria - Stratum P (parent): * Biological parent of Stratum A participant
References
Publications (1)
- DERIVEDPinto EM, Maxwell KN, Halalsheh H, Phillips A, Powers J, MacFarland S, Walsh MF, Breen K, Formiga MN, Kriwacki R, Nichols KE, Mostafavi R, Wang J, Clay MR, Rodriguez-Galindo C, Ribeiro RC, Zambetti GP. Clinical and Functional Significance of TP53 Exon 4-Intron 4 Splice Junction Variants. Mol Cancer Res. 2022 Feb;20(2):207-216. doi: 10.1158/1541-7786.MCR-21-0583. Epub 2021 Oct 21. PMID 34675114