Clinical trial · Interventional
Ipsilateral Hepatic Vein Embolization After Portal Vein Embolization
Sequential Preoperative Ipsilateral Hepatic Vein Embolization After Portal Vein Embolization to Induce Further Liver Regeneration in Patients With Hepatobiliary Malignancy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Portal vein embolization (PVE) induces shrinkage of the embolized lobe and compensatory enlargement of the non-embolized lobe, but it does not always induce sufficient liver regeneration. There was no effective method to accelerate liver regeneration in addition to PVE yet. This study intends to assess the effect of ipsilateral hepatic vein embolization (HVE) performed after Portal vein embolization (PVE) on liver regeneration. During a 1-year study period, preoperative HVE would be performed on 10 or more patients who had shown limited liver regeneration after PVE awaiting right hepatectomy. Sequential application of PVE and HVE may be safe and effective in facilitating contralateral liver regeneration by inducing more severe liver damage than PVE alone.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Degree of Liver Regeneration | — | UNRESOLVED | — |
| Procedure-Related Complication | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Right hepatic vein embolization | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- HVE
- description
- Hepatic vein embolization after portal vein embolization
- interventionNames
- Procedure: Right hepatic vein embolization
- type
- NO_INTERVENTION
- label
- PVE
- description
- Only portal vein embolization, historical control group
Primary outcomes (1)
- measure
- Future remnant left liver volume on multidetector dynamic CT scans
- timeFrame
- 2 weeks after HVE
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Patients showing small future remnant liver \< 40% of whole liver volume Exclusion Criteria: * Patients showing small future remnant liver \> 40% of whole liver volume * Inoperable tumor extent
References
Publications (0)
Data not yet available