Dose-Comparison Study to Evaluate the Safety and Immunogenicity of MEDI-517 (GSK 580299) in Healthy Adult Females

Inclusion Criteria:

* Females 18 through 30 years of age (must not have reached the 31st birthday)
* Unless previously surgically sterilized, agrees to use an effective method of birth control beginning 30 days before the first study injection and continuing through 60 days after the final study injection
* Healthy by medical history and physical examination
* Seronegative for HPV-16 and HPV-18 antibody by ELISA within 21 days of study entry
* Cervical specimen negative for high-risk HPV DNA using the Digene Hybrid Capture® II HPV test (high-risk types Probe B) within 21 days of study entry
* Normal Pap smear, using the Cytyc ThinPrep® Pap Test, within 21 days of study entry
* No evidence of anogenital HPV lesions or no physical findings suggestive of other gynecologic pathogens on pelvic examination within 21 days of study entry
* Agrees to no other experimental therapy or vaccines until 30 days after the last study injection
* Written informed consent obtained from the volunteer

Exclusion Criteria:

* Acute illness or fever (oral temperature ≥ 99.5°F \[37.5°C\]) at start of the study
* History or clinical manifestations of significant medical or psychiatric disorder
* Pregnant or lactating
* Use of immunosuppressive medication within the previous 90 days or history of immunodeficiency
* History of cancer
* History of alcohol or drug abuse within the past 2 years
* Abnormal laboratory values in the screening panel which in the opinion of the principal investigator are judged to be clinically significant
* Receipt of immunoglobulin or blood products within 90 days prior to study entry
* History of abnormal Pap smear (other than a single prior report of ASCUS or indeterminate Pap smear with a subsequent normal report)
* Positive tests for hepatitis C antibody, hepatitis B surface antigen, or HIV-1 antibody
* Any prior receipt of any vaccine (experimental or otherwise) for treatment or prophylaxis of genital warts or other papillomavirus related condition. Any treatment of genital warts or other papillomavirus related condition within 6 months of randomization (local therapy for common skin and/or plantar warts is allowed)
* Previous administration of any components of the investigational vaccine
* Receipt of any experimental vaccine within 90 days prior to entry into this study
* Receipt of any experimental drug therapy within 30 days or five half-lives of the experimental drug (if the half-life is known), whichever is longer