Clinical trial · Interventional
Correlation of MR Thermal Imaging to Actual Size of Ablation During Laser Ablation Therapy
A Study to Determine Correlation of MR Thermal Imaging to Actual Size of Ablation During Laser Therapy of Metastases to Bone
NCT00688038CI-TRIAL-00029560completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical research study is to learn how well magnetic resonance thermal imaging (MRTI) can check the amount of tumor being destroyed using a therapy called laser ablation (a procedure that uses lasers to create heat that is designed to destroy cancer cells).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Cancer | Malignant Neoplasm | CURATED_BROADER | 0.78 |
| Bone Metastases | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laser Ablation | Procedure | — | UNRESOLVED |
| Magnetic Resonance Thermal Imaging | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Laser Ablation + MRTI
- description
- Magnetic resonance thermal imaging = MRTI
- interventionNames
- Procedure: Laser Ablation
- Procedure: Magnetic Resonance Thermal Imaging
Primary outcomes (1)
- measure
- Correlation of Maximal Dimensions of 60-degree Celsius Isotherm + Ablation Zone Dimensions as determined by MRI
- timeFrame
- 2 Years
- description
- Magnetic resonance thermal imaging (MRTI) data to determine the correlation between observed temperatures determined from MRTI and the actual size of ablation as determined by post-ablation contrast-enhanced magnetic resonance imaging (MRI) during Laser Induced Thermal Therapy (LITT) of soft tissue metastases in bone.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with tumor metastases to the skeleton who are referred to interventional radiology for percutaneous ablation 2. Surgery is not a viable or desirable alternative therapy at the time of enrollment 3. Radiation therapy has failed or not indicated or can be safely postponed 4. Symptomatic or asymptomatic tumor size less than or equal to 3 cm in its largest diameter. 5. Performance status is Eastern Cooperative Oncology Group 2 or better in adults 6. Patient is able to undergo MRI 7. Patients at least 18 years of age Exclusion Criteria: 1. Patients with uncorrectable coagulopathy 2. Patients with pacemaker or defibrillator 3. Patients with metallic prosthesis at the site of the intended ablation 4. Patients with spinal cord compression or epidural tumor extension 5. Patients with vertebral body metastases exhibiting posterior wall destruction 6. Patients with any soft tissue extension of a vertebral tumor 7. Patients with any metastasis that is extrinsically located in vertebra or any long bones of the extremities compromising the cortex 8. Patients with tumors having direct extension or involvement of a joint capsule or a major nerve 9. Patients with Neutropenia (ANC less then 1000) or known active infection 10. Patients unable to undergo conscious sedation 11. Children under 18 years of age will be excluded from this study
References
Publications (0)
Data not yet available
No reference posted for this study.