Clinical trial · Interventional
Green Tea, Black Tea, or Water in Treating Patients With Prostate Cancer Undergoing Surgery
Effects of Brewed Green and Black Tea on Inflammation, Apoptosis and Oxidation in Men With Prostate Cancer
NCT00685516CI-TRIAL-00049221completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Green tea contains ingredients that may prevent or slow the growth of certain cancers. It is not yet known whether green tea is more effective than black tea or water in treating prostate cancer. PURPOSE: This randomized phase II trial is studying green tea to see how well it works compared with black tea and water in treating patients with prostate cancer undergoing surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| decaffeinated black tea | Dietary Supplement | — | UNRESOLVED |
| green tea | Dietary Supplement | — | UNRESOLVED |
| placebo | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Arm I - Green Tea
- description
- Patients receive 6 cups of green tea daily for 2-8 weeks in the absence of unacceptable toxicity.
- interventionNames
- Dietary Supplement: green tea
- type
- PLACEBO_COMPARATOR
- label
- Arm II - Water
- description
- Patients receive 6 cups of water daily for 2-8 weeks in the absence of unacceptable toxicity.
- interventionNames
- Dietary Supplement: placebo
- type
- ACTIVE_COMPARATOR
- label
- Arm III - Decaffeinated black tea
- description
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 40 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * subject consents to participate in the trial. * subject is 40-75 years of age and has a diagnosis of adenocarcinoma of the prostate. * Scheduled to undergo radical prostatectomy. * The subject agrees to stop consumption of tea or tea-containing products throughout the entire intervention period except for the tea provided during study intervention. * The subject agrees to stop consumption of dietary or vitamin supplements (e.g., lycopene, Vitamin E, selenium, genistein) or herbal supplements (e.g., saw palmetto, PC-SPES) Exclusion Criteria: * history of hepatitis or liver dysfunction * ongoing alcohol abuse * significant medical or psychiatric conditions that would make the patient a poor protocol candidate * prior sensitivity or allergic reaction to tea, tea products, or tea supplements * allergy or sensitivity to multiple food items or nutritional supplements * concurrent luteinizing hormone-releasing hormone agonists, androgen receptor blocking agents, or finasteride * prior bilateral orchiectomy
References
Publications (1)
- RESULTHenning SM, Wang P, Said JW, Huang M, Grogan T, Elashoff D, Carpenter CL, Heber D, Aronson WJ. Randomized clinical trial of brewed green and black tea in men with prostate cancer prior to prostatectomy. Prostate. 2015 Apr 1;75(5):550-9. doi: 10.1002/pros.22943. Epub 2014 Dec 24. PMID 25545744