Phase I of Human Papillomavirus (HPV) DNA Plasmid (VGX-3100) + Electroporation for CIN 2 or 3

Inclusion Criteria:

* Written informed consent in accordance with institutional guidelines;
* Female 18-45 years of age;
* Post surgical (including LEEP and conization) or ablative treatment and a diagnosis of CIN 2 or 3, while under physician care as per ASCCP guidelines (Appendix D);
* Normal ECG and normal laboratory values as judged by Grade 0-1 as per Toxicity Grading Scale for Healthy Adults (Appendix C) for CBC, CPK, SMA-12 and urinalysis evaluations done up to 30 days prior to administration of study treatment;
* Body mass index (BMI) ≤30 kg/m2;
* Women of child-bearing potential (WOCBP) agree to remain sexually abstinent, use medically effective contraception (oral contraception, barrier methods, spermicide, etc), or have a partner who is sterile (i.e., vasectomy) from enrollment to 3 months after the last injection (\~6 months);
* Able and willing to comply with all study procedures.

Exclusion Criteria:

* Active infection with herpes simplex virus (HSV);
* Positive serological test for HIV virus, hepatitis C virus or Hepatitis B virus surface antigen (HBsAg);
* Pregnant or breastfeeding subjects;
* Any concurrent condition requiring the continued use of systemic or topical steroids (excluding inhaled and eye drop-containing corticosteroids) or the use of immunosuppressive agents. All other corticosteroids must be discontinued \> 4 weeks prior to Day 1 of treatment;;
* Administration of any blood product within 3 months of enrollment;
* Administration of any vaccine within 6 weeks of enrollment;
* Patient is currently participating or has participated in a study with an investigational compound or device within 30 days of signing informed consent;
* Metal implants at the site of injection;
* Active drug or alcohol use or dependence that, in the opinion of the investigator, would interfere with adherence to study requirements;
* Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (i.e. infections disease) illness must not be enrolled into this study;
* Any other conditions judged by the investigator that would limit the evaluation of a subject.