Clinical trial · Interventional
Aerobic Exercise, Resistance Exercise, or Flexibility and Relaxation Training in Inactive Older Female Breast Cancer Survivors
Comparison of Aerobic and Resistance Exercise in Older Breast Cancer Survivors
NCT00662103CI-TRIAL-00019490completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Aerobic exercise, resistance exercise, and flexibility and relaxation training may reduce fatigue and improve the health and quality of life of breast cancer survivors. It is not yet known which type of exercise is more effective for inactive older female breast cancer survivors. PURPOSE: This randomized clinical trial is studying aerobic exercise to see how well it works compared with resistance exercise or flexibility and relaxation training in improving the health and quality of life of inactive older female breast cancer survivors.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Cancer Survivor | — | UNRESOLVED | — |
| Fatigue | — | UNRESOLVED | — |
| Long-term Effects Secondary to Cancer Therapy in Adults | — | UNRESOLVED | — |
| Psychosocial Effects of Cancer and Its Treatment | — | UNRESOLVED | — |
Interventions
Interventions (8)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| assessment of therapy complications | Procedure | — | UNRESOLVED |
| exercise intervention | Behavioral | — | UNRESOLVED |
| fatigue assessment and management | Procedure | — | UNRESOLVED |
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| management of therapy complications | Procedure | — | UNRESOLVED |
| psychosocial assessment and care | Procedure | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
| survey administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- progressive, aerobic exercise program
- description
- Patients undergo aerobic exercise training over approximately 45 minutes (not including warm-up or cool-down exercises) 3 days a week for 18 months.
- interventionNames
- Behavioral: exercise intervention
- Other: laboratory biomarker analysis
- Other: questionnaire administration
- Other: survey administration
- Procedure: assessment of therapy complications
- Procedure: fatigue assessment and management
- Procedure: management of therapy complications
- Procedure: psychosocial assessment and care
- type
- ACTIVE_COMPARATOR
- label
- progressive, resistance exercise program
- description
- Patients undergo resistance exercise training 3 days a week for 18 months.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 65 Years
- Maximum age
- 120 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Diagnosis of breast cancer * Stage 0-III disease * Completed chemotherapy or radiotherapy \> 2 years ago * Is not a regular participant in moderate aerobic exercise (i.e., jogging, swimming) or moderate resistance exercise (\> 3 times/week for ≥ 30 minutes/session) OR in vigorous aerobic or resistance exercise (\> 3 times/week for ≥ 20 minutes/session) * No stage IV breast cancer * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Menopausal status not specified * Has obtained medical clearance to participate in study exercise programs * No cognitive difficulties that would preclude answering the survey questions, participating in the performance tests, or giving informed consent * No medical condition or movement or neurological disorder that would contraindicate participation in moderate intensity exercise training, as determined by physician clearance and the Principal Investigator PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No concurrent medication that would contraindicate participation in moderate intensity exercise training, as determined by physician clearance and the Principal Investigator * Concurrent hormonal therapy (e.g., selective estrogen receptor modulator (SERM) or aromatase inhibitor) for breast cancer allowed
References
Publications (2)
- DERIVEDWinters-Stone KM, Torgrimson-Ojerio B, Dieckmann NF, Stoyles S, Mitri Z, Luoh SW. A randomized-controlled trial comparing supervised aerobic training to resistance training followed by unsupervised exercise on physical functioning in older breast cancer survivors. J Geriatr Oncol. 2022 Mar;13(2):152-160. doi: 10.1016/j.jgo.2021.08.003. Epub 2021 Aug 21. PMID 34426142
- DERIVEDWinters-Stone KM, Wood LJ, Stoyles S, Dieckmann NF. The Effects of Resistance Exercise on Biomarkers of Breast Cancer Prognosis: A Pooled Analysis of Three Randomized Trials. Cancer Epidemiol Biomarkers Prev. 2018 Feb;27(2):146-153. doi: 10.1158/1055-9965.EPI-17-0766. Epub 2017 Nov 15. PMID 29141853