Clinical trial · Interventional
Exercise for Physical Health in Men With Prostate Cancer
NCT00660686CI-TRIAL-00019546completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to conduct a 12-month randomized controlled trial comparing the effects of strength and impact exercise training to flexibility/relaxation training on body composition (bone, muscle and fat mass), physical function (strength, gait, power, balance and self-report physical function and symptoms) in men currently treated with hormone therapy for prostate cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Osteoporosis | — | UNRESOLVED | — |
| Prostatic Neoplasm | Prostate Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Flexibility Training | Behavioral | — | UNRESOLVED |
| Resistance Exercise | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 1
- description
- Progressive resistance training program 3 times a week for 12 months
- interventionNames
- Behavioral: Resistance Exercise
- type
- ACTIVE_COMPARATOR
- label
- 2
- description
- Seated flexibility training 3 times a week for 12 months
- interventionNames
- Behavioral: Flexibility Training
Primary outcomes (1)
- measure
- bone mineral density, bone turnover markers (serum osteocalcin, urinary deoxypyridinoline cross-links), muscle mass, fat mass.
- timeFrame
- 12 months
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * histologically confirmed prostate cancer * presently receiving or planning to begin androgen deprivation therapy for prostate cancer Exclusion Criteria: * Presence of bone metastases in the proximal femur and lumbar spine * Clinically defined osteoporosis * Current or previous use of medications known to affect bone metabolism * Current regular participation (\>2x/wk for at least 30 min/session) in a planned session of moderate-vigorous impact or resistance training * A medical condition, disorder, or medication that contraindicates participation in moderate intensity impact or resistance exercise
References
Publications (2)
- DERIVEDErnst M, Wagner C, Oeser A, Messer S, Wender A, Cryns N, Brockelmann PJ, Holtkamp U, Baumann FT, Wiskemann J, Monsef I, Scherer RW, Mishra SI, Skoetz N. Resistance training for fatigue in people with cancer. Cochrane Database Syst Rev. 2024 Nov 28;11(11):CD015518. doi: 10.1002/14651858.CD015518. PMID 39606939
- DERIVEDWinters-Stone KM, Dobek JC, Bennett JA, Dieckmann NF, Maddalozzo GF, Ryan CW, Beer TM. Resistance training reduces disability in prostate cancer survivors on androgen deprivation therapy: evidence from a randomized controlled trial. Arch Phys Med Rehabil. 2015 Jan;96(1):7-14. doi: 10.1016/j.apmr.2014.08.010. Epub 2014 Sep 3. PMID 25194450