MRI Study With Ferumoxytol in Assessing Early Response in Patients With Glioblastoma Multiforme Receiving Temozolomide and Radiation Therapy

Inclusion Criteria:

* Patients must have radiologically and histologically confirmed diagnosis of glioblastoma multiforme
* Patients must have measurable disease, defined as evident tumors with gadolinium enhancement on MRI that is measurable in at least one diameter and visible on both axial and sagittal or coronal views
* Life expectancy of greater than 6 months
* Eastern Cooperative Oncology Group (ECOG) performance status =\< 2 (Karnofsky \>= 50%)
* Patients scheduled for standard therapy (6 weeks radiation therapy (RT) \~ 60 Gy, plus temozolomide 75 mg/m\^2 during 6 week \[w\] RT, and followed routine monthly temozolomide therapy)
* Patients must be on a stable or decreasing dose (up to 8 mg daily) of dexamethasone throughout the study
* After entry into the study, patients are expected to be followed for at least 1 month after the last infusion of ferumoxytol
* Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately
* Ability to understand and the willingness to sign a written informed consent document; all patients, or their legal guardians, must sign a written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization in accordance with institutional guidelines

Exclusion Criteria:

* Patients who have had chemotherapy or radiotherapy
* Patients may not be receiving any other investigational agents
* History of allergic reactions attributed to compounds of similar chemical or biologic composition to ferumoxytol: parenteral iron, parenteral dextran, parenteral iron-dextran, or parenteral iron-polysaccharide preparations (Ferumoxytol Investigator's Drug Brochure, 2005); patients with significant drug or other allergies or autoimmune diseases may be enrolled at the Investigator's discretion
* Patients with clinically significant signs of uncal herniation, such as acute pupillary enlargement, rapidly developing motor changes (over hours), or rapidly decreasing level of consciousness, are not eligible
* Patients who require monitored anesthesia for MRI scanning
* Patients with history of hemochromatosis or iron overload
* Patients with renal insufficiency (glomerular filtration rate (GFR) \< 50)
* Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
* Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with ferumoxytol
* Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible