Clinical trial · Interventional
Evaluation of Patients With Breast Cancer Using DCE-MRI, MRS, and Proteomics
Evaluation of Patients With Breast Cancer Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, and Proteomics
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Diagnostic procedures, such as dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI), magnetic resonance spectroscopy (MRS), and tissue proteomics, may help doctors find and diagnose breast cancer and plan the best treatment. PURPOSE: This clinical trial is studying MRI and MRS with or without tissue proteomics analysis to see how well they work in evaluating healthy women and women who are undergoing surgery for breast cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| dynamic contrast-enhanced magnetic resonance imaging | Procedure | — | UNRESOLVED |
| histopathologic examination | Procedure | — | UNRESOLVED |
| lumpectomy or mastectomy | Procedure | — | UNRESOLVED |
| magnetic resonance spectroscopy | Procedure | — | UNRESOLVED |
| proteomic profiling | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Women with breast cancer
- description
- Patients undergo DCE-MRI and MRS prior to their breast cancer surgery.
- interventionNames
- Genetic: proteomic profiling
- Procedure: lumpectomy or mastectomy
- Procedure: dynamic contrast-enhanced magnetic resonance imaging
- Procedure: histopathologic examination
- Procedure: magnetic resonance spectroscopy
- type
- NO_INTERVENTION
- label
- Healthy volunteers
- description
- Women without breast cancer undergo DCE-MRI and MRS.
Primary outcomes (1)
- measure
- Correlation of data obtained by DCE-MRI and magnetic resonance spectroscopy (MRS) with data obtained by conventional X-ray mammography, tissue proteomics, and histopathology in women with breast cancer
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Meets 1 of the following criteria: * Women with breast tumors planning to undergo surgical resection * Healthy volunteers, including any constitutionally healthy female with no history of breast cancer * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Female * Menopausal status not specified * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * Not acutely ill * No non-magnetic resonance-compatible ferromagnetic materials present in the body PRIOR CONCURRENT THERAPY: * Prior chemotherapy and/or radiotherapy allowed
References
Publications (0)
Data not yet available