Clinical trial · Interventional
Endo-Laparoscopic Approach Versus Conventional Open Surgery in Obstructing Left-sided Colon Cancer: RCT
Endo-Laparoscopic Approach Versus Conventional Open Surgery in the Management of Obstructing Left-sided Colon Cancer: A Randomized Trial
NCT00654212CI-TRIAL-00017796completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Objective: Whether temporary endoscopic decompression by Self-expanding metal stents (SEMS) could allow these patients to undergo successful laparoscopic resection (endo-laparoscopic approach) has never been previously studied. This randomized trial aims to compare this approach with emergency open surgery in the management of obstructing left-sided colon cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colonic Neoplasms | Colon Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| endo-laparoscopic approach | Procedure | — | UNRESOLVED |
| open approach | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- 1
- description
- endoluminal stenting followed by laparoscopic resection (endo-laparoscopic limb, the study group)
- interventionNames
- Procedure: endo-laparoscopic approach
- type
- OTHER
- label
- 2
- description
- emergency open surgery (open limb, the control group)
- interventionNames
- Procedure: open approach
Primary outcomes (1)
- measure
- successful one-stage operation
- timeFrame
- till end of the study
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Consecutive adult patients (aged 18 or above) presenting with clinical features of left colonic obstruction were potential candidates. * In the absence of peritonitis, right lower quadrant tenderness or grossly distended caecum (10cm or above in maximal dimension) on plain abdominal radiograph, an urgent water-soluble single contrast enema was performed to determine the level of obstruction within 24 hours of admission. * Patients were recruited if the lower border of an obstructing tumour was found between the splenic flexure and rectosigmoid junction. * Informed consent was obtained from every patient recruited in the trial. Exclusion Criteria: * Patients who did not give informed consent * Patients who were considered unfit for operative treatment * Patients with previous laparotomy * Patients with clinically palpable tumor on abdominal examination.
References
Publications (1)
- DERIVEDCheung HY, Chung CC, Tsang WW, Wong JC, Yau KK, Li MK. Endolaparoscopic approach vs conventional open surgery in the treatment of obstructing left-sided colon cancer: a randomized controlled trial. Arch Surg. 2009 Dec;144(12):1127-32. doi: 10.1001/archsurg.2009.216. PMID 20026830