Clinical trial · Interventional
Energy Balance Interventions for Colorectal Cancer Prevention
NCT00653484CI-TRIAL-00013006completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Calories and physical exercise may affect the risk of developing cancer. It is not yet known whether a low-calorie diet and/or physical activity program is effective in preventing cancer in participants at increased risk of developing colorectal cancer. PURPOSE: This randomized clinical trial is studying diet and physical activity in healthy overweight, obese, or inactive participants at risk of developing colorectal cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Obesity | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Energy Restriction | Behavioral | — | UNRESOLVED |
| Physical Activity | Behavioral | — | UNRESOLVED |
| Physical Activity and Energy Restriction | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Physical Activity Only
- description
- Physical Activity
- interventionNames
- Behavioral: Physical Activity
- type
- EXPERIMENTAL
- label
- Dietary Energy Restriction
- description
- Energy restriction
- interventionNames
- Behavioral: Energy Restriction
- type
- EXPERIMENTAL
- label
- Physical Activity+Dietary Energy Restriction
- description
- Physical Activity ad Energy Restriction
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria:
DISEASE CHARACTERISTICS:
* Healthy participants at increased risk for developing colorectal cancer due to any of the following risk factors:
* Excess weight or obesity
* Body mass index 25-40 kg/m²
* Not currently exercising on a regular basis (\< 1,000 kcal/week)
* Must be free of significant eating disorders (i.e., purging, extended fasting, or use of laxatives)
PATIENT CHARACTERISTICS:
* Females must be postmenopausal, defined by the absence of menstrual periods in the past 12 months
* No heart disease or orthopedic impairments that would limit exercise or may be worsened by exercise
* No major chronic diseases (e.g., liver, kidney, diabetes, or adrenal ailments) that would influence metabolism
* No cancer diagnoses within the past 5 years, except skin cancer
Exclusion Criteria:
PRIOR CONCURRENT THERAPY:
* See Disease CharacteristicsReferences
Publications (0)
Data not yet available
No reference posted for this study.