Clinical trial · Interventional
The Effects of MBSR in Improving Immune Response to Human Papillomavirus in Patients With Cervical Dysplasia
Effects of Mindfulness-Based Stress Reduction (MBSR) on Immune Response to HPV
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Mindfulness-based stress reduction (MBSR) may reduce patient stress and improve quality of life. It is not yet known whether mindfulness-based stress reduction is effective in improving immune response to human papillomavirus in patients with cervical dysplasia. PURPOSE: This randomized clinical trial is studying whether mindfulness-based stress reduction (MBSR) or a general diet and physical activity program has any effects on immune response to human papillomavirus in patients with cervical dysplasia.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
| Precancerous Condition | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Healthy Lifestyles | Behavioral | — | UNRESOLVED |
| Mindfulness-Based Stress Reduction | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Mindfulness-based stress reduction
- description
- The MBSR program includes meditation techniques, body scan, awareness of breathing, mindful yoga, eating meditation, and walking meditation, and meets for 2 hours, once weekly for 8 weeks.
- interventionNames
- Behavioral: Mindfulness-Based Stress Reduction
- type
- PLACEBO_COMPARATOR
- label
- Healthy Lifestyles Program
- description
- The Healthy Lifestyles Program includes information on nutrition and physical activity, and meets for 2 hours, once weekly for 8 weeks.
- interventionNames
- Behavioral: Healthy Lifestyles
Primary outcomes (1)
- measure
- Comparison of indices of psychosocial well-being between the mindfulness-based stress reduction (MBSR) and control groups
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Referred for a colposcopy following an abnormal Pap smear test result * Atypical squamous cells of undetermined significance/positive for human papilloma virus or mild to moderate dysplasia * Referred for a second opinion OR patient of record within the medical practice who is undergoing routine recommended follow-up * Recruited from Fox Chase Cancer Center or Thomas Jefferson University Hospital * No history of cervical cancer * No evidence of present invasive carcinoma PATIENT CHARACTERISTICS: * Must be able to read and/or communicate in English * Not pregnant * No known HIV positivity * No psychiatric disorder or other disorder that would preclude informed consent PRIOR CONCURRENT THERAPY: * Not specified
References
Publications (0)
Data not yet available