Clinical trial · Observational
Predictive Blood Tests for Severe Radiation Reactions in Breast Cancer Patients
NCT00652678CI-TRIAL-00054612terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Lack of funding
Summary
Brief summary (as posted)
Some patients who undergo breast cancer treatment with lumpectomy followed by radiation therapy develop significant late skin and soft tissue changes, resulting in a poor cosmetic outcome. The goal of this study is to try to predict severe tissue reactions by using a combination of three of the latest blood tests, one of which we have developed ourselves.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Abnormalities, Radiation-Induced | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- correlation of the results obtained from the three blood tests with the clinical assessments of cosmetic outcome for each subject
- timeFrame
- at least 2.5 years following lumpectomy and radiation therapy
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 48 Years
Show eligibility criteria text
Inclusion Criteria: * Breast cancer treatment: lumpectomy followed by external beam XRT to breast * Age at the time of radiotherapy treatment: 45-65 years old * XRT dose to breast: \>/= 4500 and \</= 5200 cGy, fraction size 180 or 200 cGy * Dose distribution: no area receiving \>/= 112% of prescribed dose * Follow-ups: patients must be \>/= 2.5 years post-treatment Exclusion Criteria: * Reconstructive surgery to involved breast
References
Publications (0)
Data not yet available
No reference posted for this study.