Clinical trial · Interventional
A Study to Test V930/V932 in Patients With Cancers Expressing Human Epidermal Growth Factor Receptor 2 (HER-2) and/or Carcinoembryonic Antigen (CEA)(V930-003)(COMPLETED)
A Phase I Study to Evaluate the Safety/Tolerability and Immunogenicity of V930/V932 in Patients With Cancer Expressing HER-2 and/or CEA
NCT00647114CI-TRIAL-00017132completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Treatment of patients with cancer types known to express the HER-2 and/or CEA tumor antigens.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| V930 | Biological | — | UNRESOLVED |
| V932 | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 1
- description
- V930
- interventionNames
- Biological: V930
- type
- EXPERIMENTAL
- label
- 2
- description
- V932
- interventionNames
- Biological: V932
Primary outcomes (1)
- measure
- To determine the safety and tolerability of V930/V932 followed by EP in cancer patients
- timeFrame
- Week 22
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients must have completed surgical treatment for his/her primary disease at least 1 month prior to enrollment * Patient must not be pregnant 3 days prior to enrollment Exclusion Criteria: * Patient is currently participating or has participated in a study with an investigational compound or device within 30 days of signing informed consent * Patient has had their spleen removed or has a history of autoimmune disorders * Patient is a regular user of any illicit drugs or has used within the past year of drug or alcohol abuse * Patient is pregnant or breastfeeding or is expecting to conceive anytime following the study * Patient is known to be Human Immunodeficiency Virus (HIV)-seropositive * Patient has a known history of Hepatitis B or C * Patient has received a vaccine for any disease or condition within one month of enrollment * Patient has a primary central nervous system tumor.
References
Publications (1)
- DERIVEDDiaz CM, Chiappori A, Aurisicchio L, Bagchi A, Clark J, Dubey S, Fridman A, Fabregas JC, Marshall J, Scarselli E, La Monica N, Ciliberto G, Montero AJ. Phase 1 studies of the safety and immunogenicity of electroporated HER2/CEA DNA vaccine followed by adenoviral boost immunization in patients with solid tumors. J Transl Med. 2013 Mar 8;11:62. doi: 10.1186/1479-5876-11-62. PMID 23497415