Clinical trial · Observational
Assessment of Cardiovascular Risk Markers in Growth Hormone Deficient Patients With Nonsecreting Pituitary Adenomas
Assessment of Cardiovascular Risk Markers in GH Deficient Patients With Nonsecreting Pituitary Adenomas
NCT00646308CI-TRIAL-00004734terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Poor enrollment
Summary
Brief summary (as posted)
The purpose of this study is to determine if patients with a history of nonsecreting pituitary adenomas with untreated GH deficient patients have profiles consistent with increased cardiovascular risk compared to patients without GH deficiency who have undergone similar surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Growth Hormone Deficiency | — | UNRESOLVED | — |
| Pituitary Tumor | Pituitary Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- I
- description
- Adult patients with GH deficiency due to a nonsecreting pituitary tumor
- label
- 2
- description
- Adult patients with a nonsecreting pituitary tumor but without GH deficiency
Primary outcomes (1)
- measure
- Cardiovascular risk markers, specifically lipids, CRP, IL6 and homocysteine
- timeFrame
- One time point
Secondary outcomes (1)
- measure
- Total body fat, trunk fat and lean body mass by DEXA, insulin sensitivity, flow mediated dilatation and endothelial cell biopsy, carotid IMT, intramyocellular and intrahepatic lipid content.
- timeFrame
- One time point
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients with a history of a nonsecreting pituitary tumor with or without prior pituitary surgery. Exclusion Criteria: * Current use of GH therapy or within the prior 3 months. Pituitary tumor necessitating surgery.
References
Publications (0)
Data not yet available
No reference posted for this study.