Clinical trial · Interventional
Randomized Controlled Trial of Gemcitabine Combined With 125I Brachytherapy
Randomized Controlled Trial of Gemcitabine Combined With 125I Brachytherapy Versus Gemcitabine Alone in Patients With Locally Advanced Pancreatic Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
For patients with unresectable locally advanced pancreatic cancer, the combined use of external-beam radiation therapy (EBRT) and systemic chemotherapy of 5-FU has been widely recognized as the most effective chemoradiotherapy approach.But most patients succumb to local recurrence and metastasis after treatment, and the prognosis remains poor On the basis of the development and superiority of the interstitial brachytherapy and the radiosensitizing effect of gemcitabine, we performed a clinical study to explore the interaction of improved I-125 brachytherapy and gemcitabine and compare the regimen to the standard gemcitabine treatment specifically in patients with non-metastatic, unresectable pancreatic cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Locally Advanced Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 125I brachytherapy PLUS gemcitabine | Other | — | UNRESOLVED |
| gemcitabine | Drug | Gemcitabine | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- A
- interventionNames
- Drug: gemcitabine
- type
- EXPERIMENTAL
- label
- B
- interventionNames
- Other: 125I brachytherapy PLUS gemcitabine
Primary outcomes (1)
- measure
- Survival
- timeFrame
- 2 years after the inclusion of the last patient
Secondary outcomes (1)
- measure
- response rate, clinical benefit response, and safety
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically proven * locally advanced pancreatic adenocarcinoma stage * No systemic metastases * Age between 18-75 * Karnofsky-Performance Status equal to, or greater than 70 % * At least a 2-dimensionally measurable tumor lesion * Adequate renal and liver function * Written consent statement * Patients' compliance and geographical proximity * Life expectancy equal to or greater than 3 months Exclusion Criteria: * Serious psychological disease * Pregnancy and inadequate or not secure contraception or breastfeeding women * Other previous malignant disease in the past two years * Serious systemic concomitant diseases, excluding participation in a trial * Other experimental treatment during or within 6 weeks prior to this trial (including chemotherapeutic medicine or immune-therapies) * Every other condition or therapy assessed by the physician as an eventual risk for the patient or restricting the aims of the trial * Distant metastasis
References
Publications (0)
Data not yet available