Correlation of X-ray and Pathology With Needle Biopsy of Lung Tumors

The purpose of this study is to compare the features that the pathologist sees, when examining a lung tumor under the microscope, to the way that the tumor appears on the computed tomography (CT) scan. Features of the tumor may include abnormal blood vessels and areas in which tumor cells are dying. The samples that are taken during the needle biopsy contain information from one small part of the tumor. The investigators believe that they can show where in the tumor the samples came from, based on the CT scans during the biopsy procedure. If the investigators can accurately determine where in the tumor their samples came from, they can compare the features of that part of the tumor, as seen on the CT images, to the features of that part of the tumor as seen under the microscope. This research study also will give the investigators an idea of how much the biopsy samples are distorted in the process of preparing them for examination under the microscope.

Sex

All

Minimum age

18 Years

Inclusion Criteria:

* Subjects who have a lung tumor that is likely to be malignant
* Subjects who have been referred for percutaneous needle biopsy
* The target lesion must be at least 10 mm in short-axis dimension.
* Subjects must have intravenous access.
* No history of significant allergy to intravenous contrast.
* Subjects must have sufficient renal function to receive intravenous contrast for enhancement of the CT images.

Exclusion Criteria:

* Vulnerable populations will be excluded.
* Subjects who lack the capacity to provide consent
* Subjects who are pregnant