Clinical trial · Interventional
Prevention of Hypocalcemia in Patients Undergoing Total Thyroidectomy Plus Central Neck Dissection
Phase 2 Study of Routine Oral Calcium and Vitamine D Supplements to Prevent Hypocalcemia After Total Thyroidectomy in Papillary Thyroid Carcinoma Patients
NCT00630214CI-TRIAL-00001334completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
the increased risk of hypocalcemia following total thyroidectomy plus central neck dissection can be minimized by routine administration of oral calcium and vitamin D supplements during the early postoperative period.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hypocalcemia | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Oral calcium alone | Dietary Supplement | — | UNRESOLVED |
| Oral calcium plus vitamin D | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- NO_INTERVENTION
- label
- C
- description
- No supplements after total thyroidectomy and central neck dissection
- type
- NO_INTERVENTION
- label
- D
- description
- No central neck dissection group (total thyroidectomy alone)
- type
- ACTIVE_COMPARATOR
- label
- A
- description
- Oral calcium plus vitamin D supplements after total thyroidectomy and central neck dissection
- interventionNames
- Dietary Supplement: Oral calcium plus vitamin D
- type
- ACTIVE_COMPARATOR
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 15 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Differentiated papillary thyroid carcinoma * Undergoing total thyroidectomy plus central neck dissection Exclusion Criteria: * Previous thyroid or neck surgery * Patients with parathyroid diseases * Other thyroid malignancies * Early loss of follow-up without proper evaluation of postoperative serum calcium levels and symptoms
References
Publications (3)
- BACKGROUNDBellantone R, Lombardi CP, Raffaelli M, Boscherini M, Alesina PF, De Crea C, Traini E, Princi P. Is routine supplementation therapy (calcium and vitamin D) useful after total thyroidectomy? Surgery. 2002 Dec;132(6):1109-12; discussion 1112-3. doi: 10.1067/msy.2002.128617. PMID 12490862
- RESULTMoore FD Jr. Oral calcium supplements to enhance early hospital discharge after bilateral surgical treatment of the thyroid gland or exploration of the parathyroid glands. J Am Coll Surg. 1994 Jan;178(1):11-6. PMID 8156110
- DERIVEDRoh JL, Park JY, Park CI. Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differentiated papillary thyroid carcinoma undergoing total thyroidectomy plus central neck dissection. Cancer. 2009 Jan 15;115(2):251-8. doi: 10.1002/cncr.24027. PMID 19117033