Clinical trial · Observational
CT Scans in Screening for Lung Cancer in Current and Former Smokers
Development of a Lung Cancer-Screening Program at the University of Nebraska Medical Center: A Feasibility Study
NCT00625690CI-TRIAL-00069921completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Screening tests, such as CT scanning, may help doctors find cancer cells early and plan better treatment for lung cancer. PURPOSE: This clinical trial is studying how well a lung cancer screening program using CT scanning works in current and former smokers.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| computed tomography | Procedure | — | UNRESOLVED |
| evaluation of cancer risk factors | Procedure | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
| study of high risk factors | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (8)
- measure
- Feasibility of establishing a lung cancer screening program at the University of Nebraska Medical Center
- timeFrame
- Upon the approximately 5-year establishment of normative parameters in regard to screening efficiency.
- description
- Frequency of suspicious nodules on baseline CT; Frequency of invasive procedures for diagnosis; Frequency of surgical evaluation; Complication rates with diagnostic work up as well as surgical management.
- measure
- Feasibility of screening 100 high-risk individuals with high-resolution CT scanning for the presence of suspicious pulmonary nodules
- timeFrame
- Upon the approximately 5-year establishment of normative parameters in regard to screening efficiency.
- description
- Enrollment of 100 subjects; Baseline and yearly CT evaluations for 4 more years.
- measure
- Comparison of work-up on all study participants with abnormal results within a defined time period from initial screening
- timeFrame
- Upon the approximately 5-year establishment of normative parameters in regard to screening efficiency.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
- Maximum age
- 120 Years
Show eligibility criteria text
Inclusion Criteria: * Current and former smokers with at least a 30 pack-year history of smoking * Body weight less than 140 kg (308 pounds) * Able to lie flat * Able to comply with long-term follow-up * Functional capacity and willingness to undergo diagnostic work-up of suspicious nodules and curative therapy if lung cancer is detected * Nursing mothers allowed * Able to come to clinic for screening Exclusion Criteria: * No cognitive impairment that would preclude providing informed consent * No other concurrent or prior malignancy within the past five years except superficial basal cell carcinoma or nonmelanoma skin cancer * No condition that would preclude screening, diagnosis, or surgical treatment * Not pregnant/negative pregnancy test
References
Publications (0)
Data not yet available
No reference posted for this study.