Clinical trial · Interventional
Optical Spectroscopy in Evaluating Tumor Margins in Patients Who Have Undergone Surgery for Breast Tumors
Breast Tumor Detection Using Optical Spectroscopy
NCT00625417CI-TRIAL-00065280completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Diagnostic procedures, such as optical spectroscopy, may help learn the extent of disease and allow doctors to plan better treatment. PURPOSE: This phase I trial is studying optical spectroscopy to see how well it works in evaluating tumor margins in patients who have undergone surgery for breast cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| breast biopsy | Procedure | — | UNRESOLVED |
| histopathologic examination | Procedure | — | UNRESOLVED |
| light-scattering spectroscopy | Procedure | — | UNRESOLVED |
| therapeutic conventional surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Optical spectroscopy on tumor margins
- description
- Optical spectroscopy is performed on breast tumor margins obtained from patients undergoing surgery
- interventionNames
- Procedure: breast biopsy
- Procedure: histopathologic examination
- Procedure: light-scattering spectroscopy
- Procedure: therapeutic conventional surgery
Primary outcomes (2)
- measure
- Development of a non-invasive detection tool that evaluates breast tumor margins in real-time to guide tumor resection during partial mastectomy procedures
- timeFrame
- 1 year
- description
- A 3-D scanner that can scan a breast lump will be developed so that breast margin may be evaluated with Raman spectroscopy
- measure
- Evaluated optical spectroscopy in differentiating breast tumor or tumor margins from normal breast tissue
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Scheduled to undergo lumpectomy, partial or radical mastectomy, or excisional biopsy for breast tumor at Vanderbilt University Hospital * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Male or female * Menopausal status not specified * Not pregnant PRIOR CONCURRENT THERAPY: * See Disease Characteristics INCLUSION CRITERIA Only adult patients between the ages of 18-99 years with breast tumor undergoing lumpectomy, radical mastectomy or excisional biopsy procedure will be considered EXCLUSION CRITERIA Pregnant women will be excluded from the participation.
References
Publications (0)
Data not yet available
No reference posted for this study.