Clinical trial · Observational
Biological, Genetic, and Lifestyle Risk Factors for Developing Colorectal Adenomas or Polyps in Participants Undergoing Colonoscopy
Tennessee Colorectal Polyp Study
NCT00625066CI-TRIAL-00099144completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Collecting and storing samples of tissue, blood, and other body fluids to test in the laboratory and gathering information about health and lifestyle from participants may help doctors learn more about cancer risk factors. PURPOSE: This clinical trial is looking at biological, genetic, and lifestyle risk factors for developing colorectal adenomas or polyps in participants undergoing colonoscopy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Precancerous Condition | — | UNRESOLVED | — |
Interventions
Interventions (8)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| biologic sample preservation procedure | Other | — | UNRESOLVED |
| biopsy | Procedure | — | UNRESOLVED |
| cytology specimen collection procedure | Other | — | UNRESOLVED |
| evaluation of cancer risk factors | Procedure | — | UNRESOLVED |
| medical chart review | Other | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
| screening colonoscopy | Procedure | — | UNRESOLVED |
| survey administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (4)
- measure
- Recruitment of 7,000 participants who are planning to undergo colonoscopy
- measure
- Collection of questionnaires and medical records
- measure
- Collection of biological samples, including urine, blood, buccal cells and/or saliva, rectal tissue, and colorectal polyps
- measure
- Evaluation of risk factors and other differences between participants found to have polyps and those who do not have polyps
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 75 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Scheduled to undergo colonoscopy at the Vanderbilt University Medical Center or the Tennessee Valley Veterans Administration Medical Center * No prior genetic colorectal cancer syndromes or colorectal adenoma PATIENT CHARACTERISTICS: * Must have a permanent residence and a telephone number * Able to speak and understand English * No prior inflammatory bowel disease * No prior cancer other than nonmelanoma skin cancer * Not a current resident in a correctional facility * No other rare exclusion that would prevent the collection of study data (e.g., extensive memory loss for past exposures), impair ability to provide informed consent, or make the participant an atypical colonoscopy patient (e.g., colonoscopy for organ transplant evaluation) * No prior extensive knowledge or contact with the investigation/protocol/hypotheses (the study collaborator or reviewer) PRIOR CONCURRENT THERAPY: * No prior partial or complete colon resection * No concurrent participation in a clinical trial involving the prevention of colon polyps
References
Publications (1)
- DERIVEDMurff HJ, Shrubsole MJ, Cai Q, Smalley WE, Dai Q, Milne GL, Ness RM, Zheng W. Dietary intake of PUFAs and colorectal polyp risk. Am J Clin Nutr. 2012 Mar;95(3):703-12. doi: 10.3945/ajcn.111.024000. Epub 2012 Jan 25. PMID 22277551