Blood Stem Cell Transplantation for the Treatment of Older Patients With Acute Myelogenous Leukemia

Inclusion Criteria:

For Study Registration:

* Age 55 - 70 years.
* Subjects diagnosed with AML (\> 20% myeloblasts).

For Proceeding to Transplant:

* Subjects must be in either complete remission (CR) or partial remission (PR) within 14 days prior to admission.
* Subjects must be \> 21 days since completion of prior systemic chemotherapy or radiation therapy (including craniospinal XRT), prior to admission .
* Organ function requirements for a reduced intensity (FluBu2) regimen (must be met within 21 days of admission):

  * Cardiac: LV Ejection Fraction \> 40% on MUGA or Echocardiogram.
  * Pulmonary: FEV1 and FVC \> 40% predicted, DLCO \> 40% of predicted.
  * Renal: Serum creatinine \< 2.0 mg/dl. Not on hemodialysis or continuous veno-venous filtration (CVVH).
  * Hepatic: serum total bilirubin \< 3.0 mg/dl and AST / ALT \< 4x ULN
  * Karnofsky \> 60%.
* Organ function requirements for a full intensity (FluBu4) regimen (must be met within 21 days of admission):

  * Cardiac: LV Ejection Fraction \> 40% on MUGA or Echocardiogram.
  * Pulmonary: FEV1 and FVC \> 50% predicted, DLCO (corrected for hemoglobin) \> 50% of predicted.
  * Renal: serum creatinine \< 2.0 mg/dl. Not on hemodialysis or continuous veno-venous filtration (CVVH)
  * Hepatic: serum total bilirubin \< 3.0 mg/dl and AST / ALT \< 4x ULN.
  * Karnofsky \> 60%.

Exclusion Criteria:

For Study Registration:

* Subjects with M3 AML (FAB classification)

For Proceeding to Transplant:

* Subjects who exhibit signs of progressive disease (\> 20% blasts) within 14 days prior to admission for transplant
* Patients with an uncontrolled viral or fungal infection within the prior 28 days.
* Patients who are HIV1 or HIV2 positive.
* Uncontrollable medical or psychiatric disorder