Topical Myristyl Nicotinate Cream on the Skin of Healthy Volunteers

Inclusion Criteria:

* Subjects 18 years of age or older with normal skin
* Have used no topical medications on the skin of the upper extremities, except for emollients or sunscreens, for at least 30 days prior to study entry
* Agree to limit sun exposure as much as possible and wear protective clothing on the forearms in place of using sunscreens or moisturizers
* Ability to understand and willingness to sign an informed consent before initiation of therapy after the nature of the study has been explained to them
* Females must be surgically sterile by hysterectomy or post menopausal

Exclusion Criteria:

* Subjects with no signs of inflammation or irritation of the skin on the forearms
* Subjects with prior history of actinic keratosis or skin cancer on the forearm
* Females of child bearing potential
* Subjects with any concurrent therapy (e.g., retinoids, fluorouracil) on the forearms that may interfere with clinical evaluations
* Subjects taking oral supplemental niacin, by itself or in the form of a multi-vitamin that exceeds 40 mg/day
* No known immunosuppression by virtue of medication or disease, including AIDS patients, subjects taking oral prednisone, and subjects on immunosuppressants/immunomodulators( cyclosporine, chemotherapeutic agents, or biologic therapy), determined by the examining investigator/co-investigator
* Uncontrolled intercurrent illness including, but not limited to any of ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
* Subjects who have had invasive cancer within the past 5 years
* Skin conditions felt by the study physician to contraindicate enrollment including, but not limited to, psoriasis or atopic dermatitis within a proposed treatment area
* Less than 30 days since prior and no concurrent or planned participation in another clinical trial