Clinical trial · Interventional
Effect of Pulmonary Rehabilitation on Surgical Outcomes in the Cancer Setting
The Efficacy of Pulmonary Rehabilitation in Improving Surgical Eligibility for Lung Resection
NCT00618553CI-TRIAL-00118178active not recruitingPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical research study is to see if pulmonary rehabilitation can improve patients' lung function, which would increase their chances of becoming eligible for surgery. The health of pulmonary rehabilitation participants after surgery will also be examined.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Pulmonary Rehabilitation | Behavioral | — | UNRESOLVED |
| Questionnaire | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Pulmonary Rehabilitation
- description
- Pulmonary Rehabilitation - Rehabilitation treatment given over about 3-4 weeks. Questionnaire regarding quality-of-life that lasts about 30 minutes.
- interventionNames
- Other: Questionnaire
- Behavioral: Pulmonary Rehabilitation
Primary outcomes (1)
- measure
- Treatment Success (conversion from ineligible to eligible status for lung resection following Pulmonary rehabilitation (PR))
- timeFrame
- Baseline and post treatment (following 3-4 weeks of PR)
Secondary outcomes (1)
- measure
- Examine health of pulmonary rehabilitation participants after surgery.
- timeFrame
- 2 Years
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Patients with anatomically resectable lung tumors who are deemed surgically inoperable based on preoperative pulmonary function testing FEV1 \< 80% pred; DLCO \< 80% pred; FEV1ppo \< 40% pred; DLCO ppo \< 40% pred AND VO2 peak \< 60% predicted or \< 15 ml/kg/min. 2. Patients deemed surgically inoperable based on poor performance status (ECOG score 2-3) 3. Any non-pulmonary co-morbidity must be stable according to institutional guidelines. Exclusion Criteria: 1. Previously reported severe pulmonary hypertension (pulmonary artery systolic pressure \> 60 as determined by echocardiogram), refractory cor pulmonale (as manifested by right ventricular dilatation or dysfunction by echocardiogram) 2. Previously reported exercise-induced syncope, angina, palpitation, arrhythmia, hypotension (drop of 20% of systolic/diastolic from baseline) 3. History of severe congestive heart failure (NYHA class 3 and 4) refractory to medical management, (LVEF \< 40% by echocardiogram). 4. Bone metastasis 5. Active psychiatric illness that could interfere with treatment.
References
Publications (0)
Data not yet available
No reference posted for this study.