Clinical trial · Interventional
Narrow Band Imaging Colon Polyp Study
A Multicenter, Prospective, Randomized Controlled Trial for the Detection of Colon Polyps and Predicting Histology
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this study the investigators hypothesize that High Definition White Light colonoscopy and narrow band imaging (NBI) will detect a higher number of adenomas compared to standard definition white light colonoscopy. NBI will have a higher accuracy in predicting polyp histology compared to high definition colonoscopy and standard colonoscopy. Specific Aim 1 - To compare the prevalence of adenomas detected by standard colonoscopy, high-definition white light colonoscopy and NBI. Specific Aim 2 - To compare the number of adenoma detected per subject by standard colonoscopy, high-definition white light colonoscopy and NBI. Specific Aim 3 - To compare the accuracy of predicting polyp histology between standard colonoscopy, high-definition white light colonoscopy and NBI by evaluating the surface mucosal and vascular patterns during the procedure. Specific Aim 4 - To determine the inter-observer agreement between investigators for the recognition of various polyp patterns
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenomatous Polyp | Adenomatous Polyp | ONTOLOGY_EXACT | 0.98 |
| New Imaging Techniques in Colonoscopy | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| colonoscopy | Procedure | — | UNRESOLVED |
| standard of care colonoscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- 1
- description
- Standard White Light Colonoscopy
- interventionNames
- Procedure: standard of care colonoscopy
- type
- EXPERIMENTAL
- label
- 2
- description
- High Definition White Light Colonoscopy
- interventionNames
- Procedure: standard of care colonoscopy
- type
- EXPERIMENTAL
- label
- 3
- description
- Narrow Band Imaging Colonoscopy
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion criteria: * referral for screening or surveillance colonoscopy * the ability to provide informed consent Exclusion criteria: * prior surgical resection of any portion of colon * prior history of colon cancer * history of inflammatory bowel disease * use of anti-platelet agents or anticoagulants that precludes removal of polyps during the procedure * poor general condition or any other reason to avoid prolonged procedure time * history of polyposis syndrome or HNPCC * inability to give informed consent. * Inadequate bowel preparation
References
Publications (1)
- DERIVEDRastogi A, Early DS, Gupta N, Bansal A, Singh V, Ansstas M, Jonnalagadda SS, Hovis CE, Gaddam S, Wani SB, Edmundowicz SA, Sharma P. Randomized, controlled trial of standard-definition white-light, high-definition white-light, and narrow-band imaging colonoscopy for the detection of colon polyps and prediction of polyp histology. Gastrointest Endosc. 2011 Sep;74(3):593-602. doi: 10.1016/j.gie.2011.04.050. Epub 2011 Jul 29. PMID 21802078